TY - JOUR
T1 - Alcohol intake and pancreatic cancer
T2 - A pooled analysis from the pancreatic cancer cohort consortium (PanScan)
AU - Michaud, Dominique S.
AU - Vrieling, Alina
AU - Jiao, Li
AU - Mendelsohn, Julie B.
AU - Steplowski, Emily
AU - Lynch, Shannon M.
AU - Wactawski-Wende, Jean
AU - Arslan, Alan A.
AU - Bas Bueno-De-Mesquita, H.
AU - Fuchs, Charles S.
AU - Gross, Myron
AU - Helzlsouer, Kathy
AU - Jacobs, Eric J.
AU - Lacroix, Andrea
AU - Petersen, Gloria
AU - Zheng, Wei
AU - Allen, Naomi
AU - Ammundadottir, Laufey
AU - Bergmann, Manuela M.
AU - Boffetta, Paolo
AU - Buring, Julie E.
AU - Canzian, Federico
AU - Chanock, Stephen J.
AU - Clavel-Chapelon, Françoise
AU - Clipp, Sandra
AU - Freiberg, Matthew S.
AU - Michael Gaziano, J.
AU - Giovannucci, Edward L.
AU - Hankinson, Susan
AU - Hartge, Patricia
AU - Hoover, Robert N.
AU - Allan Hubbell, F.
AU - Hunter, David J.
AU - Hutchinson, Amy
AU - Jacobs, Kevin
AU - Kooperberg, Charles
AU - Kraft, Peter
AU - Manjer, Jonas
AU - Navarro, Carmen
AU - Peeters, Petra H.M.
AU - Shu, Xiao Ou
AU - Stevens, Victoria
AU - Thomas, Gilles
AU - Tjønneland, Anne
AU - Tobias, Geoffrey S.
AU - Trichopoulos, Dimitrios
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Virtamo, Jarmo
AU - Wallace, Robert
AU - Wolpin, Brian M.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
AU - Stolzenberg-Solomon, Rachael Z.
PY - 2010/8
Y1 - 2010/8
N2 - The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.
AB - The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.
KW - Alcohol
KW - Pancreatic cancer
KW - Pooled analysis
UR - http://www.scopus.com/inward/record.url?scp=77955708474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955708474&partnerID=8YFLogxK
U2 - 10.1007/s10552-010-9548-z
DO - 10.1007/s10552-010-9548-z
M3 - Article
C2 - 20373013
AN - SCOPUS:77955708474
SN - 0957-5243
VL - 21
SP - 1213
EP - 1225
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 8
ER -