Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis

Lindsay M. Morton; Tongzhang Zheng; Theodore R. Holford; Elizabeth A. Holly; Brian C.H. Chiu; Adele Seniori Costantini; Emanuele Stagnaro; Eleanor V. Willett; Luigino Dal Maso; Diego Serraino; Ellen T. Chang; Wendy Cozen; Scott Davis; Richard K. Severson; Leslie Bernstein; Susan T. Mayne; Fred R. Dee; James R. Cerhan; Patricia Hartge

doi:10.1016/S1470-2045(05)70214-X

Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis

Lindsay M. Morton, Tongzhang Zheng, Theodore R. Holford, Elizabeth A. Holly, Brian C.H. Chiu, Adele Seniori Costantini, Emanuele Stagnaro, Eleanor V. Willett, Luigino Dal Maso, Diego Serraino, Ellen T. Chang, Wendy Cozen, Scott Davis, Richard K. Severson, Leslie Bernstein, Susan T. Mayne, Fred R. Dee, James R. Cerhan, Patricia Hartge

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Background: Previous epidemiological studies of the relation between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) have been inconsistent, probably because of small sample sizes of individual studies that result from stratification by NHL subtype and type of alcoholic beverage. We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype. Methods: We obtained original data from nine case-control studies from the USA, UK, Sweden, and Italy in the International Lymphoma Epidemiology Consortium (InterLymph), yielding a pooled study population of 15175 individuals (6492 cases and 8683 controls). We derived odds ratios (OR) and 95% CI from unconditional logistic regression models, controlling for study centre and other confounding factors. Heterogeneity between studies was assessed by comparison of results from joint fixed-effects logistic regression and two-stage random-effects logistic regression, and by calculation of Wald χ² statistics. Findings: People who drank alcohol had a lower risk of NHL than did non-drinkers (OR 0·83 [95% CI 0·76-0·89]). Compared with non-drinkers, risk estimates were lower for current drinkers than for former drinkers (0·73 [0·64-0·84] vs 0·95 [0·80-1·14]), but risk did not decrease with increasing alcohol consumption. The protective effect of alcohol did not vary by beverage type, but did change with NHL subtype. The lowest risk estimates were recorded for Burkitt's lymphoma (0·51 [0·33-0·77]). Interpretation: People who drink alcoholic beverages might have a lower risk of NHL than those who do not, and this risk might vary by NHL subtype. Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association.

Original language	English (US)
Pages (from-to)	469-476
Number of pages	8
Journal	Lancet Oncology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1016/S1470-2045(05)70214-X
State	Published - Jul 2005

ASJC Scopus subject areas

Oncology

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Morton, L. M., Zheng, T., Holford, T. R., Holly, E. A., Chiu, B. C. H., Costantini, A. S., Stagnaro, E., Willett, E. V., Dal Maso, L., Serraino, D., Chang, E. T., Cozen, W., Davis, S., Severson, R. K., Bernstein, L., Mayne, S. T., Dee, F. R., Cerhan, J. R., & Hartge, P. (2005). Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis. Lancet Oncology, 6(7), 469-476. https://doi.org/10.1016/S1470-2045(05)70214-X

Morton, LM, Zheng, T, Holford, TR, Holly, EA, Chiu, BCH, Costantini, AS, Stagnaro, E, Willett, EV, Dal Maso, L, Serraino, D, Chang, ET, Cozen, W, Davis, S, Severson, RK, Bernstein, L, Mayne, ST, Dee, FR, Cerhan, JR & Hartge, P 2005, 'Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis', Lancet Oncology, vol. 6, no. 7, pp. 469-476. https://doi.org/10.1016/S1470-2045(05)70214-X

@article{052f72c1ecfe4a5ba69c60731cf4f2e1,

title = "Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis",

abstract = "Background: Previous epidemiological studies of the relation between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) have been inconsistent, probably because of small sample sizes of individual studies that result from stratification by NHL subtype and type of alcoholic beverage. We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype. Methods: We obtained original data from nine case-control studies from the USA, UK, Sweden, and Italy in the International Lymphoma Epidemiology Consortium (InterLymph), yielding a pooled study population of 15175 individuals (6492 cases and 8683 controls). We derived odds ratios (OR) and 95% CI from unconditional logistic regression models, controlling for study centre and other confounding factors. Heterogeneity between studies was assessed by comparison of results from joint fixed-effects logistic regression and two-stage random-effects logistic regression, and by calculation of Wald χ2 statistics. Findings: People who drank alcohol had a lower risk of NHL than did non-drinkers (OR 0·83 [95% CI 0·76-0·89]). Compared with non-drinkers, risk estimates were lower for current drinkers than for former drinkers (0·73 [0·64-0·84] vs 0·95 [0·80-1·14]), but risk did not decrease with increasing alcohol consumption. The protective effect of alcohol did not vary by beverage type, but did change with NHL subtype. The lowest risk estimates were recorded for Burkitt's lymphoma (0·51 [0·33-0·77]). Interpretation: People who drink alcoholic beverages might have a lower risk of NHL than those who do not, and this risk might vary by NHL subtype. Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association.",

author = "Morton, {Lindsay M.} and Tongzhang Zheng and Holford, {Theodore R.} and Holly, {Elizabeth A.} and Chiu, {Brian C.H.} and Costantini, {Adele Seniori} and Emanuele Stagnaro and Willett, {Eleanor V.} and {Dal Maso}, Luigino and Diego Serraino and Chang, {Ellen T.} and Wendy Cozen and Scott Davis and Severson, {Richard K.} and Leslie Bernstein and Mayne, {Susan T.} and Dee, {Fred R.} and Cerhan, {James R.} and Patricia Hartge",

note = "Funding Information: This pooled analysis was supported by grant CA10349 from the US National Cancer Institute (NCI). Individual studies that contributed data to this pooled analysis were supported by: grant CA62006 from NCI (Connecticut study); contracts PC65064, PC67008, PC67009, PC67010, and PC71105 from NCI (NCI-SEER study); grant 99B083 from the American Institute for Cancer Research (Nebraska study); grants CA89745 and CA45614 from NCI (UCSF study); grant CA50850 from NCI (USC study); the National Research Council (CNR) Applied Project “Clinical Applications of Oncological Research” and the Italian Association for Cancer Research (northern Italy study); the Leukaemia Research Fund (UK study); grant CA51086 from NCI, the European Community (Europe Against Cancer Programme), and the Lega Italiana per la Lotta Contro i Tumori (Italy study); and grant CA69269 from NCI and the Stockholm Cancer Foundation (Cancerf{\"o}reningen) (Sweden study). We thank the InterLymph Consortium and the current InterLymph executive committee (Martha Linet, Paolo Boffetta, and Bruce Armstrong) for support.",

year = "2005",

month = jul,

doi = "10.1016/S1470-2045(05)70214-X",

language = "English (US)",

volume = "6",

pages = "469--476",

journal = "Lancet Oncology",

issn = "1470-2045",

publisher = "Lancet Publishing Group",

number = "7",

}

TY - JOUR

T1 - Alcohol consumption and risk of non-Hodgkin lymphoma

T2 - A pooled analysis

AU - Morton, Lindsay M.

AU - Zheng, Tongzhang

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Chiu, Brian C.H.

AU - Costantini, Adele Seniori

AU - Stagnaro, Emanuele

AU - Willett, Eleanor V.

AU - Dal Maso, Luigino

AU - Serraino, Diego

AU - Chang, Ellen T.

AU - Cozen, Wendy

AU - Davis, Scott

AU - Severson, Richard K.

AU - Bernstein, Leslie

AU - Mayne, Susan T.

AU - Dee, Fred R.

AU - Cerhan, James R.

AU - Hartge, Patricia

N1 - Funding Information: This pooled analysis was supported by grant CA10349 from the US National Cancer Institute (NCI). Individual studies that contributed data to this pooled analysis were supported by: grant CA62006 from NCI (Connecticut study); contracts PC65064, PC67008, PC67009, PC67010, and PC71105 from NCI (NCI-SEER study); grant 99B083 from the American Institute for Cancer Research (Nebraska study); grants CA89745 and CA45614 from NCI (UCSF study); grant CA50850 from NCI (USC study); the National Research Council (CNR) Applied Project “Clinical Applications of Oncological Research” and the Italian Association for Cancer Research (northern Italy study); the Leukaemia Research Fund (UK study); grant CA51086 from NCI, the European Community (Europe Against Cancer Programme), and the Lega Italiana per la Lotta Contro i Tumori (Italy study); and grant CA69269 from NCI and the Stockholm Cancer Foundation (Cancerföreningen) (Sweden study). We thank the InterLymph Consortium and the current InterLymph executive committee (Martha Linet, Paolo Boffetta, and Bruce Armstrong) for support.

PY - 2005/7

Y1 - 2005/7

N2 - Background: Previous epidemiological studies of the relation between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) have been inconsistent, probably because of small sample sizes of individual studies that result from stratification by NHL subtype and type of alcoholic beverage. We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype. Methods: We obtained original data from nine case-control studies from the USA, UK, Sweden, and Italy in the International Lymphoma Epidemiology Consortium (InterLymph), yielding a pooled study population of 15175 individuals (6492 cases and 8683 controls). We derived odds ratios (OR) and 95% CI from unconditional logistic regression models, controlling for study centre and other confounding factors. Heterogeneity between studies was assessed by comparison of results from joint fixed-effects logistic regression and two-stage random-effects logistic regression, and by calculation of Wald χ2 statistics. Findings: People who drank alcohol had a lower risk of NHL than did non-drinkers (OR 0·83 [95% CI 0·76-0·89]). Compared with non-drinkers, risk estimates were lower for current drinkers than for former drinkers (0·73 [0·64-0·84] vs 0·95 [0·80-1·14]), but risk did not decrease with increasing alcohol consumption. The protective effect of alcohol did not vary by beverage type, but did change with NHL subtype. The lowest risk estimates were recorded for Burkitt's lymphoma (0·51 [0·33-0·77]). Interpretation: People who drink alcoholic beverages might have a lower risk of NHL than those who do not, and this risk might vary by NHL subtype. Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association.

AB - Background: Previous epidemiological studies of the relation between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) have been inconsistent, probably because of small sample sizes of individual studies that result from stratification by NHL subtype and type of alcoholic beverage. We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype. Methods: We obtained original data from nine case-control studies from the USA, UK, Sweden, and Italy in the International Lymphoma Epidemiology Consortium (InterLymph), yielding a pooled study population of 15175 individuals (6492 cases and 8683 controls). We derived odds ratios (OR) and 95% CI from unconditional logistic regression models, controlling for study centre and other confounding factors. Heterogeneity between studies was assessed by comparison of results from joint fixed-effects logistic regression and two-stage random-effects logistic regression, and by calculation of Wald χ2 statistics. Findings: People who drank alcohol had a lower risk of NHL than did non-drinkers (OR 0·83 [95% CI 0·76-0·89]). Compared with non-drinkers, risk estimates were lower for current drinkers than for former drinkers (0·73 [0·64-0·84] vs 0·95 [0·80-1·14]), but risk did not decrease with increasing alcohol consumption. The protective effect of alcohol did not vary by beverage type, but did change with NHL subtype. The lowest risk estimates were recorded for Burkitt's lymphoma (0·51 [0·33-0·77]). Interpretation: People who drink alcoholic beverages might have a lower risk of NHL than those who do not, and this risk might vary by NHL subtype. Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association.

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U2 - 10.1016/S1470-2045(05)70214-X

DO - 10.1016/S1470-2045(05)70214-X

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AN - SCOPUS:21344461216

SN - 1470-2045

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EP - 476

JO - Lancet Oncology

JF - Lancet Oncology

IS - 7

ER -

Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis

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