@article{76d3c05abf7a408b902514853f88ffd0,
title = "Alcohol consumption and pancreatic cancer: A pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)",
abstract = "Background: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. Methods: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. Results: Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. Conclusion: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.",
keywords = "Alcohol drinking, Case-control studies, Ethanol, Pancreatic cancer, Pooled analysis, Risk factors",
author = "E. Lucenteforte and {La Vecchia}, C. and D. Silverman and Petersen, {G. M.} and Bracci, {P. M.} and Ji, {B. T.} and C. Bosetti and D. Li and S. Gallinger and Miller, {A. B.} and Bueno-de-Mesquita, {H. B.} and R. Talamini and J. Polesel and P. Ghadirian and Baghurst, {P. A.} and W. Zatonski and E. Fontham and Bamlet, {W. R.} and Holly, {E. A.} and Gao, {Y. T.} and E. Negri and M. Hassan and M. Cotterchio and J. Su and P. Maisonneuve and P. Boffetta and Duell, {E. J.}",
note = "Funding Information: The Italian and Milan studies were supported by the Italian Association for Cancer Research. The Louisiana State University study was supported by the Louisiana Board of Regents Millennium Trust Health Excellence Fund [Project 5: HEF (2000-05, Genetics Studies in the Acadian Population)]. The NCI study was supported by the Intramural Research Program of the National Institute of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics (N01-CP-51090, N01-CP-51089, N01-CP-51092, N01-CP-05225, N01-CP-31022, N01-CP-05227). The Montreal investigation in the SEARCH study was supported by the Cancer Research Society, the Toronto contribution was supported by the National Cancer Institute of Canada, and the Netherlands investigation was supported by the Dutch Ministry of Public Health, Welfare and Sports (formerly Welfare, Health, and Culture). The University of California-San Francisco (UCSF) study work was supported in part by National Cancer Institute grants (CA098889 to E.J.D., CA59706, CA108370, CA109767, CA89726 to E.A.H.), and by the Rombauer Pancreatic Cancer Research Fund. Cancer incidence data collection in the UCSF study was supported by the California Department of Public Health, the National Cancer Institute{\textquoteright}s Surveillance, Epidemiology and End Results Program contract N01-PC-35136 awarded to the Northern California Cancer Center. E.L. was supported by Environmental Cancer Risk, Nutrition and Individual Susceptibility [European Union, Sixth Framework Program (FP6) Network of Excellence] and the Province of Milan. At Catalan Institute of Oncology, E.J.D. was supported by ISCIII of the Spanish Ministry of Health (RETICC DR06/ 0020).",
year = "2012",
month = feb,
doi = "10.1093/annonc/mdr120",
language = "English (US)",
volume = "23",
pages = "374--382",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "2",
}