Alcohol-Associated Liver Disease

Mengfei Liu; Tejasav S. Sehrawat; Gyongyi Szabo; Vijay H. Shah

doi:10.1007/978-3-030-51709-0_20

Alcohol-Associated Liver Disease

Mengfei Liu, Tejasav S. Sehrawat, Gyongyi Szabo, Vijay H. Shah

Gastroenterology and Hepatology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.

Original language	English (US)
Title of host publication	Liver Immunology
Subtitle of host publication	Principles and Practice
Publisher	Springer International Publishing
Pages	309-324
Number of pages	16
ISBN (Electronic)	9783030517090
ISBN (Print)	9783030517083
DOIs	https://doi.org/10.1007/978-3-030-51709-0_20
State	Published - Nov 3 2020

Keywords

Adaptive immunity
Adipose-liver axis
Alcohol
Alcohol use disorder
Alcohol-associated liver disease
Alcoholic hepatitis
Alcoholic liver disease
Chemokine
Corticosteroids
Cytokine
Gut-liver axis
Inflammasome
Inflammation
Innate immunity
Pattern recognition receptors
TLRs

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1007/978-3-030-51709-0_20

Cite this

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title = "Alcohol-Associated Liver Disease",

abstract = "This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.",

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AU - Szabo, Gyongyi

AU - Shah, Vijay H.

PY - 2020/11/3

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N2 - This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.

AB - This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.

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KW - Adipose-liver axis

KW - Alcohol

KW - Alcohol use disorder

KW - Alcohol-associated liver disease

KW - Alcoholic hepatitis

KW - Alcoholic liver disease

KW - Chemokine

KW - Corticosteroids

KW - Cytokine

KW - Gut-liver axis

KW - Inflammasome

KW - Inflammation

KW - Innate immunity

KW - Pattern recognition receptors

KW - TLRs

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BT - Liver Immunology

PB - Springer International Publishing

ER -

Alcohol-Associated Liver Disease

Abstract

Keywords

ASJC Scopus subject areas

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