Alcohol-Associated Liver Disease

Mengfei Liu, Tejasav S. Sehrawat, Gyongyi Szabo, Vijay H. Shah

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.

Original languageEnglish (US)
Title of host publicationLiver Immunology
Subtitle of host publicationPrinciples and Practice
PublisherSpringer International Publishing
Pages309-324
Number of pages16
ISBN (Electronic)9783030517090
ISBN (Print)9783030517083
DOIs
StatePublished - Nov 3 2020

Keywords

  • Adaptive immunity
  • Adipose-liver axis
  • Alcohol
  • Alcohol use disorder
  • Alcohol-associated liver disease
  • Alcoholic hepatitis
  • Alcoholic liver disease
  • Chemokine
  • Corticosteroids
  • Cytokine
  • Gut-liver axis
  • Inflammasome
  • Inflammation
  • Innate immunity
  • Pattern recognition receptors
  • TLRs

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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