Abstract
This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects of alcohol and its metabolites, innate and adaptive immune responses, and intracellular signaling pathways involved in ALD. Finally, an overview of current and emerging therapeutics will be reviewed, with a focus on immune-targeted approaches. Many of these therapies aim to translate new insights in pathogenesis of ALD into clinical treatment.
Original language | English (US) |
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Title of host publication | Liver Immunology |
Subtitle of host publication | Principles and Practice |
Publisher | Springer International Publishing |
Pages | 309-324 |
Number of pages | 16 |
ISBN (Electronic) | 9783030517090 |
ISBN (Print) | 9783030517083 |
DOIs | |
State | Published - Nov 3 2020 |
Keywords
- Adaptive immunity
- Adipose-liver axis
- Alcohol
- Alcohol use disorder
- Alcohol-associated liver disease
- Alcoholic hepatitis
- Alcoholic liver disease
- Chemokine
- Corticosteroids
- Cytokine
- Gut-liver axis
- Inflammasome
- Inflammation
- Innate immunity
- Pattern recognition receptors
- TLRs
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology