Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Young Pyo Kim, Sae Bin Jung, Dong Hoon Shin, Hong Kim, Sung Soo Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalNeuroscience Letters
Volume329
Issue number2
DOIs
StatePublished - Aug 30 2002

Keywords

  • Adolescence
  • Alcohol
  • Nicotine
  • Raphe nuclei
  • Serotonin
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

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