Alcohol and gastric acid secretion in humans

Suresh T Chari, S. Teyssen, M. V. Singer

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has either no effect or a mildly inhibitory one. Pure ethanol given by any route does not cause release of gastrin in humans. Alcoholic beverages with low ethanol content (beer and wine) are strong stimulants of gastric acid secretion and gastrin release, the effect of beer being equal to the maximal acid output. Beverages with a higher ethanol content (whisky, gin, cognac) do not stimulate gastric acid secretion or release of gastrin. The powerful stimulants of gastric acid secretion present in beer, which are yet to be identified, are thermostable and anionic polar substances. The effect of chronic alcohol abuse on gastric acid secretion is not as predictable. Chronic alcoholic patients may have normal, enhanced, or diminished acid secretory capacity; hypochlorhydria being associated histologically with atrophic gastritis. There are no studies on the acute effect of alcohol intake on gastric acid secretion in chronic alcoholic patients. The acid stimulatory component of beer and wine needs to be characterised and its possible role in the causation of alcohol induced gastrointestinal diseases needs to be investigated.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalGut
Volume34
Issue number6
StatePublished - 1993
Externally publishedYes

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Gastric Acid
Ethanol
Alcohols
Gastrins
Alcoholic Beverages
Acids
Beverages
Wine
Alcoholics
Achlorhydria
Atrophic Gastritis
Gastrointestinal Diseases
Causality
Alcoholism

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chari, S. T., Teyssen, S., & Singer, M. V. (1993). Alcohol and gastric acid secretion in humans. Gut, 34(6), 843-847.

Alcohol and gastric acid secretion in humans. / Chari, Suresh T; Teyssen, S.; Singer, M. V.

In: Gut, Vol. 34, No. 6, 1993, p. 843-847.

Research output: Contribution to journalArticle

Chari, ST, Teyssen, S & Singer, MV 1993, 'Alcohol and gastric acid secretion in humans', Gut, vol. 34, no. 6, pp. 843-847.
Chari ST, Teyssen S, Singer MV. Alcohol and gastric acid secretion in humans. Gut. 1993;34(6):843-847.
Chari, Suresh T ; Teyssen, S. ; Singer, M. V. / Alcohol and gastric acid secretion in humans. In: Gut. 1993 ; Vol. 34, No. 6. pp. 843-847.
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