Albuminocytologic Dissociation in Posterior Reversible Encephalopathy Syndrome

Sudhir Datar, Tarun D. Singh, Jennifer E. Fugate, Jayawant Mandrekar, Alejandro Rabinstein, Sara Hocker

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objectives To describe cerebrospinal fluid (CSF) findings in patients with posterior reversible encephalopathy syndrome (PRES) and to study its association with vasogenic edema. Patients and Methods Retrospective review of 73 consecutive prospectively collected adults diagnosed with PRES from January 1, 2000, through December 31, 2014, who underwent lumbar puncture. Results Seventy-three patients (mean age, 51±17 years), were included in the analysis; of these, 50 (69%) were women. The most common causes for PRES were hypertension (n=61 [84%]) and immunosuppression (n=22 [30%]). Renal failure was present in 42 (58%) patients. The median interval between clinical onset of PRES and CSF analysis was 1 day (interquartile range [IQR], 0-2 days). The median opening pressure was 23 cm H2O or 17 mm Hg (IQR, 18-28 cm H2O or 13-21 mm Hg), although it was available in only 27 patients. The median CSF protein level was 58 mg/dL (IQR, 44-81 mg/dL; normal value,

Original languageEnglish (US)
Pages (from-to)1366-1371
Number of pages6
JournalMayo Clinic Proceedings
Issue number10
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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