Albumin In Situ Hybridization Can BePositive in Adenocarcinomas and OtherTumors From Diverse Sites

Aqsa Nasir; Heidi D. Lehrke; a. Taofic Mounajjed; Samar Said; Lizhi Zhang; Saba Yasir; Sejal S. Shah; Vishal S. Chandan; Thomas C. Smyrk; Roger K. Moreira

doi:10.1093/ajcp/aqz032

Albumin In Situ Hybridization Can BePositive in Adenocarcinomas and OtherTumors From Diverse Sites

Aqsa Nasir, Heidi D. Lehrke, a. Taofic Mounajjed, Samar Said, Lizhi Zhang, Saba Yasir, Sejal S. Shah, Vishal S. Chandan, Thomas C. Smyrk, Roger K. Moreira

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives Albumin messenger RNA (mRNA) expression is a marker ofhepatocellular differentiation. Most published data are fromreview of tissue microarrays, and albumin in situ hybridization(ISH) expression across several tumor types is incompletelycharacterized. Methods Sections from 221 tumors were evaluated for albumin mRNA.Immunohistochemistry was used to confirm diagnoses.Albumin ISH was performed according to manufacturer-provided instructions. Fifty-nine cases were evaluated with bothcommercial ISH assays. Results Albumin mRNA was detected in all hepatocellular carcinomas(HCCs) and 81% of intrahepatic cholangiocarcinomas. Lung(20%), gallbladder (39%), hepatoid pancreatic (n = 1 of 1)adenocarcinoma, breast invasive ductal carcinoma (18%), yolksac tumor (25%), and acinar cell carcinoma (29%) showedexpression. Both assays were concordant in 93% of cases. Conclusions Albumin ISH was expressed in all HCCs studied. It was alsopositive in intrahepatic cholangiocarcinoma and patchy positivein gallbladder adenocarcinoma and a subset of other neoplasms,which can be a potential pitfall.

Original language	English (US)
Pages (from-to)	190-199
Number of pages	10
Journal	American journal of clinical pathology
Volume	152
Issue number	2
DOIs	https://doi.org/10.1093/ajcp/aqz032
State	Published - 2019

ASJC Scopus subject areas

Pathology and Forensic Medicine

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title = "Albumin In Situ Hybridization Can BePositive in Adenocarcinomas and OtherTumors From Diverse Sites",

abstract = "Objectives Albumin messenger RNA (mRNA) expression is a marker ofhepatocellular differentiation. Most published data are fromreview of tissue microarrays, and albumin in situ hybridization(ISH) expression across several tumor types is incompletelycharacterized. Methods Sections from 221 tumors were evaluated for albumin mRNA.Immunohistochemistry was used to confirm diagnoses.Albumin ISH was performed according to manufacturer-provided instructions. Fifty-nine cases were evaluated with bothcommercial ISH assays. Results Albumin mRNA was detected in all hepatocellular carcinomas(HCCs) and 81% of intrahepatic cholangiocarcinomas. Lung(20%), gallbladder (39%), hepatoid pancreatic (n = 1 of 1)adenocarcinoma, breast invasive ductal carcinoma (18%), yolksac tumor (25%), and acinar cell carcinoma (29%) showedexpression. Both assays were concordant in 93% of cases. Conclusions Albumin ISH was expressed in all HCCs studied. It was alsopositive in intrahepatic cholangiocarcinoma and patchy positivein gallbladder adenocarcinoma and a subset of other neoplasms,which can be a potential pitfall.",

author = "Aqsa Nasir and Lehrke, {Heidi D.} and Mounajjed, {a. Taofic} and Samar Said and Lizhi Zhang and Saba Yasir and Shah, {Sejal S.} and Chandan, {Vishal S.} and Smyrk, {Thomas C.} and Moreira, {Roger K.}",

year = "2019",

doi = "10.1093/ajcp/aqz032",

language = "English (US)",

volume = "152",

pages = "190--199",

journal = "American journal of clinical pathology",

issn = "0002-9173",

publisher = "American Society of Clinical Pathologists",

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TY - JOUR

T1 - Albumin In Situ Hybridization Can BePositive in Adenocarcinomas and OtherTumors From Diverse Sites

AU - Nasir, Aqsa

AU - Lehrke, Heidi D.

AU - Mounajjed, a. Taofic

AU - Said, Samar

AU - Zhang, Lizhi

AU - Yasir, Saba

AU - Shah, Sejal S.

AU - Chandan, Vishal S.

AU - Smyrk, Thomas C.

AU - Moreira, Roger K.

PY - 2019

Y1 - 2019

N2 - Objectives Albumin messenger RNA (mRNA) expression is a marker ofhepatocellular differentiation. Most published data are fromreview of tissue microarrays, and albumin in situ hybridization(ISH) expression across several tumor types is incompletelycharacterized. Methods Sections from 221 tumors were evaluated for albumin mRNA.Immunohistochemistry was used to confirm diagnoses.Albumin ISH was performed according to manufacturer-provided instructions. Fifty-nine cases were evaluated with bothcommercial ISH assays. Results Albumin mRNA was detected in all hepatocellular carcinomas(HCCs) and 81% of intrahepatic cholangiocarcinomas. Lung(20%), gallbladder (39%), hepatoid pancreatic (n = 1 of 1)adenocarcinoma, breast invasive ductal carcinoma (18%), yolksac tumor (25%), and acinar cell carcinoma (29%) showedexpression. Both assays were concordant in 93% of cases. Conclusions Albumin ISH was expressed in all HCCs studied. It was alsopositive in intrahepatic cholangiocarcinoma and patchy positivein gallbladder adenocarcinoma and a subset of other neoplasms,which can be a potential pitfall.

AB - Objectives Albumin messenger RNA (mRNA) expression is a marker ofhepatocellular differentiation. Most published data are fromreview of tissue microarrays, and albumin in situ hybridization(ISH) expression across several tumor types is incompletelycharacterized. Methods Sections from 221 tumors were evaluated for albumin mRNA.Immunohistochemistry was used to confirm diagnoses.Albumin ISH was performed according to manufacturer-provided instructions. Fifty-nine cases were evaluated with bothcommercial ISH assays. Results Albumin mRNA was detected in all hepatocellular carcinomas(HCCs) and 81% of intrahepatic cholangiocarcinomas. Lung(20%), gallbladder (39%), hepatoid pancreatic (n = 1 of 1)adenocarcinoma, breast invasive ductal carcinoma (18%), yolksac tumor (25%), and acinar cell carcinoma (29%) showedexpression. Both assays were concordant in 93% of cases. Conclusions Albumin ISH was expressed in all HCCs studied. It was alsopositive in intrahepatic cholangiocarcinoma and patchy positivein gallbladder adenocarcinoma and a subset of other neoplasms,which can be a potential pitfall.

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Albumin In Situ Hybridization Can BePositive in Adenocarcinomas and OtherTumors From Diverse Sites

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