Alarmins at the maternal–fetal interface: Involvement of inflammation in placental dysfunction and pregnancy complications1

Marie Eve Brien, Bernadette Baker, Cyntia Duval, Virginie Gaudreault, Rebecca L. Jones, Sylvie Girard

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of noninfectious origin, namely caused by endogenous mediators known as “damage-associated molecular patterns (DAMPs)” or alarmins. In this manuscript, we review the mechanism by which inflammation, sterile or infectious, can alter the placenta and its function. We discuss some classical DAMPs, such as uric acid, high mobility group box 1 (HMGB1), cell-free fetal deoxyribonucleic acid (DNA) (cffDNA), S100 proteins, heat shock protein 70 (HSP70), and adenosine triphosphate (ATP) and their impact on the placenta. We focus on the main placental cells (i.e., trophoblast and Hofbauer cells) and describe the placental response to, and release of, DAMPs. We also covered the current state of knowledge about the role of DAMPs in pregnancy complications including preeclampsia, fetal growth restriction, preterm birth, and stillbirth and possible therapeutic strategies to preserve placental function.

Original languageEnglish (US)
Pages (from-to)206-212
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume97
Issue number3
DOIs
StatePublished - 2019

Keywords

  • Alarmins
  • DAMPs
  • HMGB1
  • Hofbauer cell
  • Infection
  • Inflammation
  • Lipopolysaccharides
  • Placenta
  • Sterile inflammation
  • Trophoblast
  • Uric acid

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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