Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Alanna Chamberlain, Pamela J. Schreiner, Myriam Fornage, Catherine M. Loria, David Siscovick, Eric Boerwinkle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The Thr54 allele of the intestinal fatty acid-binding protein Ala54Thr functional polymorphism (FABP2) is associated with increased fat oxidation and insulin resistance. We determined the cross-sectional associations of the FABP2 gene with lipid levels and insulin resistance in 2148 participants who completed the year-20 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study. No significant difference in total cholesterol, low-density or high-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol to total cholesterol ratio, or homeostasis model assessment of insulin resistance (HOMA-IR) was found between FABP2 genotypes. However, in the presence of a high-saturated fat diet (≥53.2 g/d, the 90th percentile for the population), the AA/AG genotypes (carriers of the Thr54 allele) of FABP2 had statistically significantly higher levels of log(HOMA-IR) (P = .006) and a lower high-density lipoprotein cholesterol to total cholesterol ratio (P = .03), and borderline statistically significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, and log(triglycerides) (P values = .08, .07, and .05, respectively) compared with those with the GG genotype (Ala54 homozygotes). Lipid levels and log(HOMA-IR) did not vary by genotype with saturated fat intake less than 53.2 g/d. Limiting dietary saturated fat intake may be particularly important among carriers of the A allele of FABP2.

Original languageEnglish (US)
Pages (from-to)1222-1228
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume58
Issue number9
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

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Fatty Acid-Binding Proteins
Insulin Resistance
Young Adult
Coronary Vessels
Fats
Lipids
Genotype
HDL Cholesterol
Homeostasis
Genes
Alleles
Cholesterol
Triglycerides
Dietary Fats
Homozygote
High Fat Diet
Hypercholesterolemia
LDL Cholesterol
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance : the Coronary Artery Risk Development in Young Adults (CARDIA) study. / Chamberlain, Alanna; Schreiner, Pamela J.; Fornage, Myriam; Loria, Catherine M.; Siscovick, David; Boerwinkle, Eric.

In: Metabolism: Clinical and Experimental, Vol. 58, No. 9, 01.09.2009, p. 1222-1228.

Research output: Contribution to journalArticle

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