Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma

Jane C. Schroeder, Andrew F. Olshan, Ralph Baric, Georgette A. Dent, Clarice R. Weinberg, Boyd Yount, James R Cerhan, Charles F. Lynch, Leonard M. Schuman, Paige E. Tolbert, Nathaniel Rothman, Kenneth P. Cantor, Aaron Blair

Research output: Contribution to journalArticle

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Abstract

The t(14;18) translocation is a common somatic mutation in non-Hodgkin's lymphoma (NHL) that is associated with bcl-2 activation and inhibition of apoptosis. We hypothesized that some risk factors might act specifically along t(14;18)-dependent pathways, leading to stronger associations with t(14;18)-positive than t(14;18)-negative non-Hodgkin's lymphoma. Archival biopsies from 182 non-Hodgkin's lymphoma cases included in a case-control study of men in Iowa and Minnesota (the Factors Affecting Rural Men, or FARM study) were assayed for t(14;18) using polymerase chain reaction amplification; 68 (37%) were t (14;18)-positive. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for various agricultural risk factors and t(14;18)-positive and -negative cases of non-Hodgkin's lymphoma, based on polytomous logistic regression models fit using the expectation-maximization (EM) algorithm. T(14;18)-positive non-Hodgkin's lymphoma was associated with farming (OR 1.4, 95% CI = 0.9-2.3), dieldrin (OR 3.7, 95% CI = 1.9-7.0), toxaphene (OR 3.0, 95% CI = 1.5-6.1), lindane (OR 2.3, 95% CI = 1.3-3.9), atrazine (OR 1.7, 95% CI = 1.0-2.8), and fungicides (OR 1.8, 95% CI = 0.9-3.6), in marked contrast to null or negative associations for the same self-reported exposures and t(14;18)-negative non-Hodgkin's lymphoma. Causal relations between agricultural exposures and t(14;18)-positive non-Hodgkin's lymphoma are plausible, but associations should be confirmed in a larger study. Results suggest that non-Hodgkin's lymphoma classification based on the t(14;18) translocation is of value in etiologic research.

Original languageEnglish (US)
Pages (from-to)701-709
Number of pages9
JournalEpidemiology
Volume12
Issue number6
DOIs
StatePublished - 2001

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Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
Toxaphene
Logistic Models
Dieldrin
Atrazine
Lindane
Agriculture
Case-Control Studies
Apoptosis
Biopsy
Polymerase Chain Reaction
Mutation
Research

Keywords

  • Agriculture
  • Bcl-2
  • Case-control studies
  • EM algorithm
  • Genes
  • Lymphoma
  • Molecular
  • Non-Hodgkin
  • Pesticides
  • Translocation (genetics)

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schroeder, J. C., Olshan, A. F., Baric, R., Dent, G. A., Weinberg, C. R., Yount, B., ... Blair, A. (2001). Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. Epidemiology, 12(6), 701-709. https://doi.org/10.1097/00001648-200111000-00020

Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. / Schroeder, Jane C.; Olshan, Andrew F.; Baric, Ralph; Dent, Georgette A.; Weinberg, Clarice R.; Yount, Boyd; Cerhan, James R; Lynch, Charles F.; Schuman, Leonard M.; Tolbert, Paige E.; Rothman, Nathaniel; Cantor, Kenneth P.; Blair, Aaron.

In: Epidemiology, Vol. 12, No. 6, 2001, p. 701-709.

Research output: Contribution to journalArticle

Schroeder, JC, Olshan, AF, Baric, R, Dent, GA, Weinberg, CR, Yount, B, Cerhan, JR, Lynch, CF, Schuman, LM, Tolbert, PE, Rothman, N, Cantor, KP & Blair, A 2001, 'Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma', Epidemiology, vol. 12, no. 6, pp. 701-709. https://doi.org/10.1097/00001648-200111000-00020
Schroeder JC, Olshan AF, Baric R, Dent GA, Weinberg CR, Yount B et al. Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. Epidemiology. 2001;12(6):701-709. https://doi.org/10.1097/00001648-200111000-00020
Schroeder, Jane C. ; Olshan, Andrew F. ; Baric, Ralph ; Dent, Georgette A. ; Weinberg, Clarice R. ; Yount, Boyd ; Cerhan, James R ; Lynch, Charles F. ; Schuman, Leonard M. ; Tolbert, Paige E. ; Rothman, Nathaniel ; Cantor, Kenneth P. ; Blair, Aaron. / Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. In: Epidemiology. 2001 ; Vol. 12, No. 6. pp. 701-709.
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AU - Weinberg, Clarice R.

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AU - Cerhan, James R

AU - Lynch, Charles F.

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AU - Blair, Aaron

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N2 - The t(14;18) translocation is a common somatic mutation in non-Hodgkin's lymphoma (NHL) that is associated with bcl-2 activation and inhibition of apoptosis. We hypothesized that some risk factors might act specifically along t(14;18)-dependent pathways, leading to stronger associations with t(14;18)-positive than t(14;18)-negative non-Hodgkin's lymphoma. Archival biopsies from 182 non-Hodgkin's lymphoma cases included in a case-control study of men in Iowa and Minnesota (the Factors Affecting Rural Men, or FARM study) were assayed for t(14;18) using polymerase chain reaction amplification; 68 (37%) were t (14;18)-positive. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for various agricultural risk factors and t(14;18)-positive and -negative cases of non-Hodgkin's lymphoma, based on polytomous logistic regression models fit using the expectation-maximization (EM) algorithm. T(14;18)-positive non-Hodgkin's lymphoma was associated with farming (OR 1.4, 95% CI = 0.9-2.3), dieldrin (OR 3.7, 95% CI = 1.9-7.0), toxaphene (OR 3.0, 95% CI = 1.5-6.1), lindane (OR 2.3, 95% CI = 1.3-3.9), atrazine (OR 1.7, 95% CI = 1.0-2.8), and fungicides (OR 1.8, 95% CI = 0.9-3.6), in marked contrast to null or negative associations for the same self-reported exposures and t(14;18)-negative non-Hodgkin's lymphoma. Causal relations between agricultural exposures and t(14;18)-positive non-Hodgkin's lymphoma are plausible, but associations should be confirmed in a larger study. Results suggest that non-Hodgkin's lymphoma classification based on the t(14;18) translocation is of value in etiologic research.

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