Agnogenic myeloid metaplasia associated with Klinefelter syndrome: A case report

Shaji K Kumar, D. M. Menke, G. W. Dewald, Gerardo Colon-Otero

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Klinefelter syndrome is the most commonly diagnosed sex chromosome disorder among males. It is usually associated with 47 chromosomes, including two Xs and one Y. The formal cytogenetic designation for Klinefelter syndrome is 47, XXY; the extra sex chromosome is due to meiotic chromosomal nondisjunction. Increased risk of various malignant diseases has been recognized among patients with different congenital chromosomal abnormalities. Since the early 1960s, numerous reports have appeared of an increased risk of malignant neoplasms among patients with Klinefelter syndrome. Evidence suggests a correlation with increased incidences of germ cell tumors and breast cancers. Whether these patients are at an increased risk of hematologic malignant disease, especially acute leukemia, is still uncertain. This report describes a patient with agnogenic myeloid metaplasia and Klinefelter syndrome, an association not previously reported.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalAnnals of Hematology
Volume81
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Klinefelter Syndrome
Primary Myelofibrosis
Germ Cell and Embryonal Neoplasms
Sex Chromosome Disorders
Sex Chromosomes
Hematologic Diseases
Cytogenetics
Chromosome Aberrations
Leukemia
Chromosomes
Breast Neoplasms
Incidence
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Agnogenic myeloid metaplasia
  • Klinefelter

ASJC Scopus subject areas

  • Hematology

Cite this

Agnogenic myeloid metaplasia associated with Klinefelter syndrome : A case report. / Kumar, Shaji K; Menke, D. M.; Dewald, G. W.; Colon-Otero, Gerardo.

In: Annals of Hematology, Vol. 81, No. 4, 2002, p. 215-218.

Research output: Contribution to journalArticle

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