TY - JOUR
T1 - Aging-related adaptations in the corticotropic axis
T2 - Modulation by gender
AU - Veldhuis, Johannes D.
AU - Keenan, Daniel M.
AU - Roelfsema, Ferdinand
AU - Iranmanesh, Ali
N1 - Funding Information:
This work was supported in part by a Merit Award from the Veterans Affairs Administration, Grants K01 AG19164 and R01 DK60717 from the National Institutes of Health (Bethesda, MD), DMS-0107680 Interdisciplinary Grant in the Mathematical Sciences from the National Science Foundation (Washington, DC), and M01 RR00585 to the General Clinical Research Center of the Mayo Clinic and Foundation from the National Center for Research Resources (Rockville, MD).
PY - 2005/12
Y1 - 2005/12
N2 - Aging is marked by depletion of adrenal androgens (DHEAs) in the face of elevated late-day total cortisol concentrations. CRH and AVP evoke greater ACTH and cortisol responses in older than young adults, especially in postmenopausal women. The joint synchrony and strength of cortisol→ACTH negative feedback decline with aging. Further studies are required to elucidate the precise mechanisms mediating and the long-term impact of impaired stress adaptations in aging.
AB - Aging is marked by depletion of adrenal androgens (DHEAs) in the face of elevated late-day total cortisol concentrations. CRH and AVP evoke greater ACTH and cortisol responses in older than young adults, especially in postmenopausal women. The joint synchrony and strength of cortisol→ACTH negative feedback decline with aging. Further studies are required to elucidate the precise mechanisms mediating and the long-term impact of impaired stress adaptations in aging.
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U2 - 10.1016/j.ecl.2005.07.014
DO - 10.1016/j.ecl.2005.07.014
M3 - Review article
C2 - 16310635
AN - SCOPUS:27944494761
SN - 0889-8529
VL - 34
SP - 993
EP - 1014
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -