Aging is marked by depletion of adrenal androgens (DHEAs) in the face of elevated late-day total cortisol concentrations. CRH and AVP evoke greater ACTH and cortisol responses in older than young adults, especially in postmenopausal women. The joint synchrony and strength of cortisol→ACTH negative feedback decline with aging. Further studies are required to elucidate the precise mechanisms mediating and the long-term impact of impaired stress adaptations in aging.
|Original language||English (US)|
|Number of pages||22|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Dec 1 2005|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism