Aging Is Associated with reduced prostacyclin-mediated dilation in the human forearm

Wayne T. Nicholson, Brianna Vaa, Christiane Hesse, John H. Eisenach, Michael J. Joyner

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Aging is associated with reduced endothelial function. There is indirect evidence for reduced prostacyclin (PGI 2)-mediated vasodilation with aging, but it is unknown whether this is because of reduced dilation to PGI 2 or altered production. In addition, the contribution of endothelial NO to PGI 2-mediated dilation is unknown. Using plethysmog-raphy to determine forearm blood flow, we studied the effect of PGI 2 in 10 older (61 to 73 years) and 10 younger (19 to 45 years) subjects using 3 escalating intra-arterial doses of PGI 2 (epoprostenol). PGI 2 was also administered after NO synthase inhibition with A G-monomethyl-L-arginine acetate. The percent of change in forearm vascular conductance (mean±SEM) from baseline after PGI 2 was significantly lower (P=0.002) in the aging individuals (52±11%, 164±23%, and 221±27% versus 115±20%, 249±19%, and 370±35%). In addition, the group-by-dose interaction was also significant (P=0.018). After NO synthase inhibition, the dose-response curve to PGI 2 was blunted in the young subjects but unchanged in the older subjects; the difference between the groups was no longer significant. Our data suggest that the reduced dilator effects of PGI 2 in older individuals are attributable to a reduction in the contribution of endothelial-derived NO versus alterations in the direct effects of PGI 2 on vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalHypertension
Volume53
Issue number6
DOIs
StatePublished - Jun 1 2009

Keywords

  • Aging
  • Blood flow
  • NO
  • Prostaglandins

ASJC Scopus subject areas

  • Internal Medicine

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