Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms

Mark J. Cartwright, Tamara Tchkonia, James L Kirkland

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Fat mass and tissue distribution change dramatically throughout life. Fat depot sizes reach a peak by middle or early old age, followed by a substantial decline, together with fat tissue dysfunction and redistribution in advanced old age. These changes are associated with health complications, including type 2 diabetes, atherosclerosis, dyslipidemia, thermal dysregulation, and skin ulcers, particularly in advanced old age. Fat tissue growth occurs through increases in size and number of fat cells. Fat cells turn over throughout the lifespan, with new fat cells developing from preadipocytes, which are of mesenchymal origin. The pool of preadipocytes comprises 15-50% of the cells in fat tissue. Since fat tissue turns over throughout life, characteristics of these cells very likely have a significant impact on fat tissue growth, plasticity, function, and distribution. The aims of this review are to highlight recent findings regarding changes in preadipocyte cell dynamics and function with aging, and to consider how inherent characteristics of these cells potentially contribute to age- and depot-dependent changes in fat tissue development and function.

Original languageEnglish (US)
Pages (from-to)463-471
Number of pages9
JournalExperimental Gerontology
Volume42
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Adipocytes
Aging of materials
Fats
Tissue
Skin Ulcer
Tissue Distribution
Dyslipidemias
Growth
Type 2 Diabetes Mellitus
Atherosclerosis
Hot Temperature
Medical problems
Plasticity
Health
Skin

Keywords

  • C/EBPα
  • CUGBP
  • Dysdifferentiation
  • PPARγ
  • Preadipocyte differentiation

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Aging in adipocytes : Potential impact of inherent, depot-specific mechanisms. / Cartwright, Mark J.; Tchkonia, Tamara; Kirkland, James L.

In: Experimental Gerontology, Vol. 42, No. 6, 06.2007, p. 463-471.

Research output: Contribution to journalArticle

Cartwright, Mark J. ; Tchkonia, Tamara ; Kirkland, James L. / Aging in adipocytes : Potential impact of inherent, depot-specific mechanisms. In: Experimental Gerontology. 2007 ; Vol. 42, No. 6. pp. 463-471.
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