Aging and hormones of the hypothalamo-pituitary axis: Gonadotropic axis in men and somatotropic axes in men and women

Johannes D Veldhuis

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Neuroendocrinology of the aging (male) gonadal and (male and female) somatotropic axes will be reviewed. A companion chapter discusses reproductive hormonal changes in aging women. Both the gonadal and growth-hormone/insulin-like growth factor (GH/IGF-I) axes function as ensembles. The ensembles comprise tripartite interactions among the brain (hypothalamus), anterior pituitary gland (gonadotrope and somatotrope cells) and target organs (testis, liver, muscle, fat and brain). Compelling evidence indicates that combined hypothalamic and gonadal adaptations operate in the reproductive axis of older men, and multiple hypothalamic adaptations prevail in the GH axis of elderly men and women. Evolving investigative methods allow more precise parsing of the particular mechanisms that subserve such age-related changes, and suggest novel interventional strategies to evaluate the physiological impact of the dynamic alterations discerned in aging individuals.

Original languageEnglish (US)
Pages (from-to)189-208
Number of pages20
JournalAgeing Research Reviews
Volume7
Issue number3
DOIs
StatePublished - Oct 2008

Fingerprint

Pituitary Hormones
Aging of materials
Neuroendocrinology
Gonadal Hormones
Anterior Pituitary Gland
Brain
Somatomedins
Insulin-Like Growth Factor I
Growth Hormone
Hypothalamus
Testis
Fats
Muscles
Liver
Muscle

Keywords

  • Androgen
  • Anterior pituitary
  • Brain
  • Gonadotropin
  • Growth hormone
  • Human
  • IGF-I
  • Luteinizing hormone
  • Men
  • Somatotropin

ASJC Scopus subject areas

  • Aging
  • Biochemistry

Cite this

Aging and hormones of the hypothalamo-pituitary axis : Gonadotropic axis in men and somatotropic axes in men and women. / Veldhuis, Johannes D.

In: Ageing Research Reviews, Vol. 7, No. 3, 10.2008, p. 189-208.

Research output: Contribution to journalArticle

@article{7c715556dbf34b9397bd760712cfbd1f,
title = "Aging and hormones of the hypothalamo-pituitary axis: Gonadotropic axis in men and somatotropic axes in men and women",
abstract = "Neuroendocrinology of the aging (male) gonadal and (male and female) somatotropic axes will be reviewed. A companion chapter discusses reproductive hormonal changes in aging women. Both the gonadal and growth-hormone/insulin-like growth factor (GH/IGF-I) axes function as ensembles. The ensembles comprise tripartite interactions among the brain (hypothalamus), anterior pituitary gland (gonadotrope and somatotrope cells) and target organs (testis, liver, muscle, fat and brain). Compelling evidence indicates that combined hypothalamic and gonadal adaptations operate in the reproductive axis of older men, and multiple hypothalamic adaptations prevail in the GH axis of elderly men and women. Evolving investigative methods allow more precise parsing of the particular mechanisms that subserve such age-related changes, and suggest novel interventional strategies to evaluate the physiological impact of the dynamic alterations discerned in aging individuals.",
keywords = "Androgen, Anterior pituitary, Brain, Gonadotropin, Growth hormone, Human, IGF-I, Luteinizing hormone, Men, Somatotropin",
author = "Veldhuis, {Johannes D}",
year = "2008",
month = "10",
doi = "10.1016/j.arr.2007.12.005",
language = "English (US)",
volume = "7",
pages = "189--208",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Aging and hormones of the hypothalamo-pituitary axis

T2 - Gonadotropic axis in men and somatotropic axes in men and women

AU - Veldhuis, Johannes D

PY - 2008/10

Y1 - 2008/10

N2 - Neuroendocrinology of the aging (male) gonadal and (male and female) somatotropic axes will be reviewed. A companion chapter discusses reproductive hormonal changes in aging women. Both the gonadal and growth-hormone/insulin-like growth factor (GH/IGF-I) axes function as ensembles. The ensembles comprise tripartite interactions among the brain (hypothalamus), anterior pituitary gland (gonadotrope and somatotrope cells) and target organs (testis, liver, muscle, fat and brain). Compelling evidence indicates that combined hypothalamic and gonadal adaptations operate in the reproductive axis of older men, and multiple hypothalamic adaptations prevail in the GH axis of elderly men and women. Evolving investigative methods allow more precise parsing of the particular mechanisms that subserve such age-related changes, and suggest novel interventional strategies to evaluate the physiological impact of the dynamic alterations discerned in aging individuals.

AB - Neuroendocrinology of the aging (male) gonadal and (male and female) somatotropic axes will be reviewed. A companion chapter discusses reproductive hormonal changes in aging women. Both the gonadal and growth-hormone/insulin-like growth factor (GH/IGF-I) axes function as ensembles. The ensembles comprise tripartite interactions among the brain (hypothalamus), anterior pituitary gland (gonadotrope and somatotrope cells) and target organs (testis, liver, muscle, fat and brain). Compelling evidence indicates that combined hypothalamic and gonadal adaptations operate in the reproductive axis of older men, and multiple hypothalamic adaptations prevail in the GH axis of elderly men and women. Evolving investigative methods allow more precise parsing of the particular mechanisms that subserve such age-related changes, and suggest novel interventional strategies to evaluate the physiological impact of the dynamic alterations discerned in aging individuals.

KW - Androgen

KW - Anterior pituitary

KW - Brain

KW - Gonadotropin

KW - Growth hormone

KW - Human

KW - IGF-I

KW - Luteinizing hormone

KW - Men

KW - Somatotropin

UR - http://www.scopus.com/inward/record.url?scp=51649122067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649122067&partnerID=8YFLogxK

U2 - 10.1016/j.arr.2007.12.005

DO - 10.1016/j.arr.2007.12.005

M3 - Article

C2 - 18343203

AN - SCOPUS:51649122067

VL - 7

SP - 189

EP - 208

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

IS - 3

ER -