Aging and cardioprotection

Arshad Jahangir, Sandeep Sagar, Andre Terzic

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Advanced age is a strong independent predictor for death, disability, and morbidity in patients with structural heart disease. With the projected increase in the elderly population and the prevalence of age-related cardiovascular disabilities worldwide, the need to understand the biology of the aging heart, the mechanisms for age-mediated cardiac vulnerability, and the development of strategies to limit myocardial dysfunction in the elderly have never been more urgent. Experimental evidence in animal models indicate attenuation in cardioprotective pathways with aging, yet limited information is available regarding age-related changes in the human heart. Human cardiac aging generates a complex phenotype, only partially replicated in animal models. Here, we summarize current understanding of the aging heart stemming from clinical and experimental studies, and we highlight targets for protection of the vulnerable senescent myocardium. Further progress mandates assessment of human tissue to dissect specific aging-associated genomic and proteomic dynamics, and their functional consequences leading to increased susceptibility of the heart to injury, a critical step toward designing novel therapeutic interventions to limit age-related myocardial dysfunction and promote healthy aging.

Original languageEnglish (US)
Pages (from-to)2120-2128
Number of pages9
JournalJournal of applied physiology
Volume103
Issue number6
DOIs
StatePublished - Dec 1 2007

Keywords

  • ATP-sensitive K channel
  • Human
  • Ischemia
  • Mitochondria
  • Postconditioning
  • Preconditioning
  • Senescence

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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