TY - JOUR
T1 - Aging and adipose tissue
T2 - potential interventions for diabetes and regenerative medicine
AU - Palmer, Allyson K.
AU - Kirkland, James L.
N1 - Publisher Copyright:
© 2016 The Authors
PY - 2016/12/15
Y1 - 2016/12/15
N2 - Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging mechanisms, including cellular senescence and progenitor cell dysfunction, occur in adipose tissue with aging and may serve as potential therapeutic targets in age-related disease. In this review, we examine the role of adipose tissue in healthy individuals and explore how aging leads to adipose tissue dysfunction, redistribution, and changes in gene regulation. Adipose tissue plays a central role in longevity, and interventions restricted to adipose tissue may impact lifespan. Conversely, obesity may represent a state of accelerated aging. We discuss the potential therapeutic potential of targeting basic aging mechanisms, including cellular senescence, in adipose tissue, using type II diabetes and regenerative medicine as examples. We make the case that aging should not be neglected in the study of adipose-derived stem cells for regenerative medicine strategies, as elderly patients make up a large portion of individuals in need of such therapies.
AB - Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging mechanisms, including cellular senescence and progenitor cell dysfunction, occur in adipose tissue with aging and may serve as potential therapeutic targets in age-related disease. In this review, we examine the role of adipose tissue in healthy individuals and explore how aging leads to adipose tissue dysfunction, redistribution, and changes in gene regulation. Adipose tissue plays a central role in longevity, and interventions restricted to adipose tissue may impact lifespan. Conversely, obesity may represent a state of accelerated aging. We discuss the potential therapeutic potential of targeting basic aging mechanisms, including cellular senescence, in adipose tissue, using type II diabetes and regenerative medicine as examples. We make the case that aging should not be neglected in the study of adipose-derived stem cells for regenerative medicine strategies, as elderly patients make up a large portion of individuals in need of such therapies.
KW - Adipose Tissue
KW - Aging
KW - Cellular Senescence
KW - Insulin Resistance
KW - Preadipocyte
KW - Stem Cell
UR - http://www.scopus.com/inward/record.url?scp=84959440332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959440332&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2016.02.013
DO - 10.1016/j.exger.2016.02.013
M3 - Review article
C2 - 26924669
AN - SCOPUS:84959440332
SN - 0531-5565
VL - 86
SP - 97
EP - 105
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -