Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men

Thomas Mulligan; Ali Iranmanesh; Michael L. Johnson; Martin Straume; Johannes D. Veldhuis

doi:10.1152/ajpregu.1997.273.4.r1407

Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men

Thomas Mulligan, Ali Iranmanesh, Michael L. Johnson, Martin Straume, Johannes D. Veldhuis

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

To discern the effect of aging on coordinate luteinizing hormone (LH) and testosterone secretion, we sampled healthy elder men (age 62-74 yr, n = 11) and young controls (age 21-34 yr, n = 13) every 2,5 min overnight. Deconvolution analysis and cross-correlation were used to relate serum LH concentrations to calculated testosterone secretion rates (feed-forward stimulation), as well as serum testosterone concentrations to computed LH secretion rates (feedback inhibition). Despite statistically similar mean serum LH and testosterone concentrations in the young and older men, older individuals had diminished feed-forward stimulation of LH concentrations on calculated testosterone secretion rates, as well as delayed feedback inhibition of testosterone concentrations on computed LH secretion rates.

Original language	English (US)
Pages (from-to)	R1407-R1413
Journal	American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume	273
Issue number	4 42-4
DOIs	https://doi.org/10.1152/ajpregu.1997.273.4.r1407
State	Published - 1997

Keywords

Age
Biological timing
Hormone secretion
Luteinizing hormone
Male

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1152/ajpregu.1997.273.4.r1407

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abstract = "To discern the effect of aging on coordinate luteinizing hormone (LH) and testosterone secretion, we sampled healthy elder men (age 62-74 yr, n = 11) and young controls (age 21-34 yr, n = 13) every 2,5 min overnight. Deconvolution analysis and cross-correlation were used to relate serum LH concentrations to calculated testosterone secretion rates (feed-forward stimulation), as well as serum testosterone concentrations to computed LH secretion rates (feedback inhibition). Despite statistically similar mean serum LH and testosterone concentrations in the young and older men, older individuals had diminished feed-forward stimulation of LH concentrations on calculated testosterone secretion rates, as well as delayed feedback inhibition of testosterone concentrations on computed LH secretion rates.",

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AU - Iranmanesh, Ali

AU - Johnson, Michael L.

AU - Straume, Martin

AU - Veldhuis, Johannes D.

PY - 1997

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AB - To discern the effect of aging on coordinate luteinizing hormone (LH) and testosterone secretion, we sampled healthy elder men (age 62-74 yr, n = 11) and young controls (age 21-34 yr, n = 13) every 2,5 min overnight. Deconvolution analysis and cross-correlation were used to relate serum LH concentrations to calculated testosterone secretion rates (feed-forward stimulation), as well as serum testosterone concentrations to computed LH secretion rates (feedback inhibition). Despite statistically similar mean serum LH and testosterone concentrations in the young and older men, older individuals had diminished feed-forward stimulation of LH concentrations on calculated testosterone secretion rates, as well as delayed feedback inhibition of testosterone concentrations on computed LH secretion rates.

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KW - Biological timing

KW - Hormone secretion

KW - Luteinizing hormone

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Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men

Abstract

Keywords

ASJC Scopus subject areas

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