Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy

Juan M. Herrerias, Jonathan A Leighton, Guido Costamagna, Anthony Infantolino, Rami Eliakim, Doron Fischer, David T. Rubin, Howard D. Manten, Eitan Scapa, Douglas R. Morgan, Ari J. Bergwerk, Binyamin Koslowsky, Samuel N. Adler

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background: Capsule endoscopy (CE) of the small bowel has become a standard diagnostic tool, but there have been concerns regarding the risk of capsule retention in certain high-risk groups. The Agile patency system, an ingestible and dissolvable capsule with an external scanner, was developed to allow physicians to perform CE with greater confidence that the capsule will be safely excreted in patients at risk for capsule retention. Objective: Our purpose was to assess the ability of the device to help physicians identify which patients with known strictures may safely undergo CE. Design: Patients with known strictures ingested the new patency capsule and underwent periodic scanning until it was excreted. The intestinal tract was considered to be sufficiently patent if the capsule was excreted intact or if the capsule was not detected by the scanner at 30 hours after ingestion. If patency was established, then standard CE was performed. Setting: International multicenter study. Patients: A total of 106 patients with known strictures. Intervention: Agile patency system. Main Outcome Measurements: Performance and safety of Agile patency system. Results: A total of 106 patients ingested the patency capsule. Fifty-nine (56%) excreted it intact and subsequently underwent CE. There were no cases of capsule retention. Significant findings on CE were found in 24 (41%). There were 3 severe adverse events. Conclusions: These results suggest that the Agile patency system is a useful tool for physicians to use before CE in patients with strictures to avoid retention. This group of patients may have a high yield of clinically significant findings at CE. This capsule may determine whether patients who have a contraindication to CE may safely undergo CE and obtain useful diagnostic information.

Original languageEnglish (US)
Pages (from-to)902-909
Number of pages8
JournalGastrointestinal Endoscopy
Volume67
Issue number6
DOIs
StatePublished - May 2008
Externally publishedYes

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Capsule Endoscopy
Capsules
Pathologic Constriction
Physicians
Multicenter Studies
Eating

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy. / Herrerias, Juan M.; Leighton, Jonathan A; Costamagna, Guido; Infantolino, Anthony; Eliakim, Rami; Fischer, Doron; Rubin, David T.; Manten, Howard D.; Scapa, Eitan; Morgan, Douglas R.; Bergwerk, Ari J.; Koslowsky, Binyamin; Adler, Samuel N.

In: Gastrointestinal Endoscopy, Vol. 67, No. 6, 05.2008, p. 902-909.

Research output: Contribution to journalArticle

Herrerias, JM, Leighton, JA, Costamagna, G, Infantolino, A, Eliakim, R, Fischer, D, Rubin, DT, Manten, HD, Scapa, E, Morgan, DR, Bergwerk, AJ, Koslowsky, B & Adler, SN 2008, 'Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy', Gastrointestinal Endoscopy, vol. 67, no. 6, pp. 902-909. https://doi.org/10.1016/j.gie.2007.10.063
Herrerias, Juan M. ; Leighton, Jonathan A ; Costamagna, Guido ; Infantolino, Anthony ; Eliakim, Rami ; Fischer, Doron ; Rubin, David T. ; Manten, Howard D. ; Scapa, Eitan ; Morgan, Douglas R. ; Bergwerk, Ari J. ; Koslowsky, Binyamin ; Adler, Samuel N. / Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy. In: Gastrointestinal Endoscopy. 2008 ; Vol. 67, No. 6. pp. 902-909.
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abstract = "Background: Capsule endoscopy (CE) of the small bowel has become a standard diagnostic tool, but there have been concerns regarding the risk of capsule retention in certain high-risk groups. The Agile patency system, an ingestible and dissolvable capsule with an external scanner, was developed to allow physicians to perform CE with greater confidence that the capsule will be safely excreted in patients at risk for capsule retention. Objective: Our purpose was to assess the ability of the device to help physicians identify which patients with known strictures may safely undergo CE. Design: Patients with known strictures ingested the new patency capsule and underwent periodic scanning until it was excreted. The intestinal tract was considered to be sufficiently patent if the capsule was excreted intact or if the capsule was not detected by the scanner at 30 hours after ingestion. If patency was established, then standard CE was performed. Setting: International multicenter study. Patients: A total of 106 patients with known strictures. Intervention: Agile patency system. Main Outcome Measurements: Performance and safety of Agile patency system. Results: A total of 106 patients ingested the patency capsule. Fifty-nine (56{\%}) excreted it intact and subsequently underwent CE. There were no cases of capsule retention. Significant findings on CE were found in 24 (41{\%}). There were 3 severe adverse events. Conclusions: These results suggest that the Agile patency system is a useful tool for physicians to use before CE in patients with strictures to avoid retention. This group of patients may have a high yield of clinically significant findings at CE. This capsule may determine whether patients who have a contraindication to CE may safely undergo CE and obtain useful diagnostic information.",
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AU - Leighton, Jonathan A

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AU - Infantolino, Anthony

AU - Eliakim, Rami

AU - Fischer, Doron

AU - Rubin, David T.

AU - Manten, Howard D.

AU - Scapa, Eitan

AU - Morgan, Douglas R.

AU - Bergwerk, Ari J.

AU - Koslowsky, Binyamin

AU - Adler, Samuel N.

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N2 - Background: Capsule endoscopy (CE) of the small bowel has become a standard diagnostic tool, but there have been concerns regarding the risk of capsule retention in certain high-risk groups. The Agile patency system, an ingestible and dissolvable capsule with an external scanner, was developed to allow physicians to perform CE with greater confidence that the capsule will be safely excreted in patients at risk for capsule retention. Objective: Our purpose was to assess the ability of the device to help physicians identify which patients with known strictures may safely undergo CE. Design: Patients with known strictures ingested the new patency capsule and underwent periodic scanning until it was excreted. The intestinal tract was considered to be sufficiently patent if the capsule was excreted intact or if the capsule was not detected by the scanner at 30 hours after ingestion. If patency was established, then standard CE was performed. Setting: International multicenter study. Patients: A total of 106 patients with known strictures. Intervention: Agile patency system. Main Outcome Measurements: Performance and safety of Agile patency system. Results: A total of 106 patients ingested the patency capsule. Fifty-nine (56%) excreted it intact and subsequently underwent CE. There were no cases of capsule retention. Significant findings on CE were found in 24 (41%). There were 3 severe adverse events. Conclusions: These results suggest that the Agile patency system is a useful tool for physicians to use before CE in patients with strictures to avoid retention. This group of patients may have a high yield of clinically significant findings at CE. This capsule may determine whether patients who have a contraindication to CE may safely undergo CE and obtain useful diagnostic information.

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