Aggressive Medulloblastoma With High-Level N-myc Amplification

FRANCIS H. TOMLINSON, ROBERT B. JENKINS, BERND W. SCHEITHAUER, PATRICK A. KEELAN, STEVE RITLAND, JOSEPH E. PARISI, JULIE CUNNINGHAM, KERRY D. OLSEN

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a “surgical metastasis” developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalMayo Clinic proceedings
Volume69
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • PCR
  • mRNA
  • messenger RNA
  • polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)

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    TOMLINSON, FRANCIS. H., JENKINS, ROBERT. B., SCHEITHAUER, BERND. W., KEELAN, PATRICK. A., RITLAND, STEVE., PARISI, JOSEPH. E., CUNNINGHAM, JULIE., & OLSEN, KERRY. D. (1994). Aggressive Medulloblastoma With High-Level N-myc Amplification. Mayo Clinic proceedings, 69(4), 359-365. https://doi.org/10.1016/S0025-6196(12)62221-6