Aggressive medulloblastoma with high-level N-myc amplification

F. H. Tomlinson, Robert Brian Jenkins, B. W. Scheithauer, P. A. Keelan, S. Ritland, Joseph E Parisi, Julie M Cunningham, K. D. Olsen

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a 'surgical metastasis' developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalMayo Clinic Proceedings
Volume69
Issue number4
StatePublished - 1994

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Medulloblastoma
myc Genes
p53 Genes
Cytogenetics
Base Pairing
Chromosome Aberrations
Cicatrix
Molecular Biology
Exons
Neoplasms
Arm
Neck
Radiotherapy
Chromosomes
Neoplasm Metastasis
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tomlinson, F. H., Jenkins, R. B., Scheithauer, B. W., Keelan, P. A., Ritland, S., Parisi, J. E., ... Olsen, K. D. (1994). Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clinic Proceedings, 69(4), 359-365.

Aggressive medulloblastoma with high-level N-myc amplification. / Tomlinson, F. H.; Jenkins, Robert Brian; Scheithauer, B. W.; Keelan, P. A.; Ritland, S.; Parisi, Joseph E; Cunningham, Julie M; Olsen, K. D.

In: Mayo Clinic Proceedings, Vol. 69, No. 4, 1994, p. 359-365.

Research output: Contribution to journalArticle

Tomlinson, FH, Jenkins, RB, Scheithauer, BW, Keelan, PA, Ritland, S, Parisi, JE, Cunningham, JM & Olsen, KD 1994, 'Aggressive medulloblastoma with high-level N-myc amplification', Mayo Clinic Proceedings, vol. 69, no. 4, pp. 359-365.
Tomlinson FH, Jenkins RB, Scheithauer BW, Keelan PA, Ritland S, Parisi JE et al. Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clinic Proceedings. 1994;69(4):359-365.
Tomlinson, F. H. ; Jenkins, Robert Brian ; Scheithauer, B. W. ; Keelan, P. A. ; Ritland, S. ; Parisi, Joseph E ; Cunningham, Julie M ; Olsen, K. D. / Aggressive medulloblastoma with high-level N-myc amplification. In: Mayo Clinic Proceedings. 1994 ; Vol. 69, No. 4. pp. 359-365.
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