Aggressive Medulloblastoma With High-Level N-myc Amplification

FRANCIS H. TOMLINSON; ROBERT B. JENKINS; BERND W. SCHEITHAUER; PATRICK A. KEELAN; STEVE RITLAND; JOSEPH E. PARISI; JULIE CUNNINGHAM; KERRY D. OLSEN

doi:10.1016/S0025-6196(12)62221-6

Aggressive Medulloblastoma With High-Level N-myc Amplification

FRANCIS H. TOMLINSON, ROBERT B. JENKINS, BERND W. SCHEITHAUER, PATRICK A. KEELAN, STEVE RITLAND, JOSEPH E. PARISI, JULIE CUNNINGHAM, KERRY D. OLSEN

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a “surgical metastasis” developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

Original language	English (US)
Pages (from-to)	359-365
Number of pages	7
Journal	Mayo Clinic proceedings
Volume	69
Issue number	4
DOIs	https://doi.org/10.1016/S0025-6196(12)62221-6
State	Published - 1994

Keywords

PCR
mRNA
messenger RNA
polymerase chain reaction

ASJC Scopus subject areas

General Medicine

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10.1016/S0025-6196(12)62221-6

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@article{97c52afef9dc426d9088a87b00b3bf35,

title = "Aggressive Medulloblastoma With High-Level N-myc Amplification",

abstract = "A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a “surgical metastasis” developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.",

keywords = "PCR, mRNA, messenger RNA, polymerase chain reaction",

author = "TOMLINSON, {FRANCIS H.} and JENKINS, {ROBERT B.} and SCHEITHAUER, {BERND W.} and KEELAN, {PATRICK A.} and STEVE RITLAND and PARISI, {JOSEPH E.} and JULIE CUNNINGHAM and OLSEN, {KERRY D.}",

note = "Funding Information: This study was supported in part by the James S. McDonnell Neurosurgical Fellowship of the Royal Brisbane Hospital Foundation, Brisbane, Queensland, Australia (F.H.T.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1994",

doi = "10.1016/S0025-6196(12)62221-6",

language = "English (US)",

volume = "69",

pages = "359--365",

journal = "Mayo Clinic proceedings",

issn = "0025-6196",

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T1 - Aggressive Medulloblastoma With High-Level N-myc Amplification

AU - TOMLINSON, FRANCIS H.

AU - JENKINS, ROBERT B.

AU - SCHEITHAUER, BERND W.

AU - KEELAN, PATRICK A.

AU - RITLAND, STEVE

AU - PARISI, JOSEPH E.

AU - CUNNINGHAM, JULIE

AU - OLSEN, KERRY D.

N1 - Funding Information: This study was supported in part by the James S. McDonnell Neurosurgical Fellowship of the Royal Brisbane Hospital Foundation, Brisbane, Queensland, Australia (F.H.T.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1994

Y1 - 1994

N2 - A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a “surgical metastasis” developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

AB - A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a “surgical metastasis” developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

KW - PCR

KW - mRNA

KW - messenger RNA

KW - polymerase chain reaction

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U2 - 10.1016/S0025-6196(12)62221-6

DO - 10.1016/S0025-6196(12)62221-6

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C2 - 8170180

AN - SCOPUS:0028316608

SN - 0025-6196

VL - 69

SP - 359

EP - 365

JO - Mayo Clinic proceedings

JF - Mayo Clinic proceedings

IS - 4

ER -

Aggressive Medulloblastoma With High-Level N-myc Amplification

Abstract

Keywords

ASJC Scopus subject areas

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