Abstract
Background: Evidence exists for an association between aggression and schizophrenia. Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia. Aims: To replicate these findings in a larger sample using the Overt Aggression Scale (OAS). Method: A sample of 180 people with DSM - IV schizophrenia were rated for aggression using the OAS. Kruskal - Wallis and contingency table analyses were applied to the OAS results. Results: The high-activity homozygotes showed significantly higher scores of aggression, whereas the heterozygotes showed significantly lower scores. The odds ratio for aggression for the high-activity homozygotes was 2.07 (95% Cl=1.03-4.15), whereas that for the heterozygotes was 0.54 (95% Cl=0.30-1.00). Conclusions: The high-activity COMT homozygote confers a higher risk of recorded aggression in schizophrenia. Heterozygotes had a significantly lower risk, which may represent an example of heterosis/heterozygote advantage.
Original language | English (US) |
---|---|
Pages (from-to) | 351-355 |
Number of pages | 5 |
Journal | British Journal of Psychiatry |
Volume | 179 |
Issue number | OCT. |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Psychiatry and Mental health