Abstract
1. Adverse thrombotic cardiovascular events increase in women coincident with the onset of menopause. 2. Age past menopause may be an important variable in defining the benefit/risk of hormone treatments. 3. Few studies have examined hormonal status as a variable of ageing using a polygenomic approach of both humoral and cellular components of the coagulation system. 4. Longitudinal studies of a global set of platelet functions that define procoagulant activity (i.e. adhesion, aggregation, secretion and thrombin production) in individuals with documented hormonal status are needed to better understand how hormonal changes associated with ageing impact thrombotic risk.
Original language | English (US) |
---|---|
Pages (from-to) | 814-821 |
Number of pages | 8 |
Journal | Clinical and Experimental Pharmacology and Physiology |
Volume | 34 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2007 |
Keywords
- 17β-oestradiol
- Energy metabolism
- Kronos Early Estrogen Prevention Study (KEEPS)
- Mitochondria
- Women's Health Initiative
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Physiology (medical)