Age-related remodeling of neuromuscular junctions

Carlos B. Mantilla, Gary C. Sieck

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Remodeling of neuromuscular junctions (NMJs) and ensuing -structural and functional plasticity occurs with aging. Age-related changes result from -reductions in physical activity, loss of motor neurons, and decreased muscle fiber size (sarcopenia). The properties of motor neurons and muscle fibers are precisely matched. In addition, motor unit recruitment in a selective manner is a primary mechanism by which the nervous system controls muscle contraction. Thus, it is essential to consider motor unit (and muscle fiber) type in any age-related -plasticity. The following chapter examines changes in motor unit properties associated with aging and how these affect structural and functional remodeling at NMJs.

Original languageEnglish (US)
Title of host publicationSarcopenia - Age-Related Muscle Wasting and Weakness
Subtitle of host publicationMechanisms and Treatments
PublisherSpringer Netherlands
Number of pages18
ISBN (Electronic)9789048197132
ISBN (Print)9789048197125
StatePublished - Jan 1 2011


  • Aging
  • Morphological adaptations
  • Motor units
  • Muscle fiber type
  • Plasticity
  • Recruitment
  • Skeletal muscle

ASJC Scopus subject areas

  • Medicine(all)


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