Age-related remodeling of neuromuscular junctions

Carlos B. Mantilla; Gary C. Sieck

doi:10.1007/978-90-481-9713-2_3

Age-related remodeling of neuromuscular junctions

Carlos B. Mantilla, Gary C. Sieck

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Remodeling of neuromuscular junctions (NMJs) and ensuing -structural and functional plasticity occurs with aging. Age-related changes result from -reductions in physical activity, loss of motor neurons, and decreased muscle fiber size (sarcopenia). The properties of motor neurons and muscle fibers are precisely matched. In addition, motor unit recruitment in a selective manner is a primary mechanism by which the nervous system controls muscle contraction. Thus, it is essential to consider motor unit (and muscle fiber) type in any age-related -plasticity. The following chapter examines changes in motor unit properties associated with aging and how these affect structural and functional remodeling at NMJs.

Original language	English (US)
Title of host publication	Sarcopenia - Age-Related Muscle Wasting and Weakness
Subtitle of host publication	Mechanisms and Treatments
Publisher	Springer Netherlands
Pages	37-54
Number of pages	18
ISBN (Electronic)	9789048197132
ISBN (Print)	9789048197125
DOIs	https://doi.org/10.1007/978-90-481-9713-2_3
State	Published - 2011

Keywords

Aging
Morphological adaptations
Motor units
Muscle fiber type
Plasticity
Recruitment
Skeletal muscle

ASJC Scopus subject areas

General Medicine

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10.1007/978-90-481-9713-2_3

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title = "Age-related remodeling of neuromuscular junctions",

abstract = "Remodeling of neuromuscular junctions (NMJs) and ensuing -structural and functional plasticity occurs with aging. Age-related changes result from -reductions in physical activity, loss of motor neurons, and decreased muscle fiber size (sarcopenia). The properties of motor neurons and muscle fibers are precisely matched. In addition, motor unit recruitment in a selective manner is a primary mechanism by which the nervous system controls muscle contraction. Thus, it is essential to consider motor unit (and muscle fiber) type in any age-related -plasticity. The following chapter examines changes in motor unit properties associated with aging and how these affect structural and functional remodeling at NMJs.",

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AU - Sieck, Gary C.

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AB - Remodeling of neuromuscular junctions (NMJs) and ensuing -structural and functional plasticity occurs with aging. Age-related changes result from -reductions in physical activity, loss of motor neurons, and decreased muscle fiber size (sarcopenia). The properties of motor neurons and muscle fibers are precisely matched. In addition, motor unit recruitment in a selective manner is a primary mechanism by which the nervous system controls muscle contraction. Thus, it is essential to consider motor unit (and muscle fiber) type in any age-related -plasticity. The following chapter examines changes in motor unit properties associated with aging and how these affect structural and functional remodeling at NMJs.

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KW - Muscle fiber type

KW - Plasticity

KW - Recruitment

KW - Skeletal muscle

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ER -

Age-related remodeling of neuromuscular junctions

Abstract

Keywords

ASJC Scopus subject areas

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