Age-related decline in BubR1 impairs adult hippocampal neurogenesis

Zhongxi Yang, Heechul Jun, Chan Ii Choi, Ki Hyun Yoo, Chang Hoon Cho, Syed Mohammed Qasim Hussaini, Ambrosia J. Simmons, Seonhee Kim, Jan Van Deursen, Darren J Baker, Mi-Hyeon D Jang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age-related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging-related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age-related cognitive deficits.

Original languageEnglish (US)
Pages (from-to)598-601
Number of pages4
JournalAging Cell
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2017

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Neurogenesis
M Phase Cell Cycle Checkpoints
Phosphotransferases
Pathology
Neurons
Brain
Therapeutics

Keywords

  • Adult neurogenesis
  • aging
  • bubR1
  • dendrite morphogenesis
  • hippocampus
  • progeroid mouse model

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Yang, Z., Jun, H., Choi, C. I., Yoo, K. H., Cho, C. H., Hussaini, S. M. Q., ... Jang, M-H. D. (2017). Age-related decline in BubR1 impairs adult hippocampal neurogenesis. Aging Cell, 16(3), 598-601. https://doi.org/10.1111/acel.12594

Age-related decline in BubR1 impairs adult hippocampal neurogenesis. / Yang, Zhongxi; Jun, Heechul; Choi, Chan Ii; Yoo, Ki Hyun; Cho, Chang Hoon; Hussaini, Syed Mohammed Qasim; Simmons, Ambrosia J.; Kim, Seonhee; Van Deursen, Jan; Baker, Darren J; Jang, Mi-Hyeon D.

In: Aging Cell, Vol. 16, No. 3, 01.06.2017, p. 598-601.

Research output: Contribution to journalArticle

Yang, Z, Jun, H, Choi, CI, Yoo, KH, Cho, CH, Hussaini, SMQ, Simmons, AJ, Kim, S, Van Deursen, J, Baker, DJ & Jang, M-HD 2017, 'Age-related decline in BubR1 impairs adult hippocampal neurogenesis', Aging Cell, vol. 16, no. 3, pp. 598-601. https://doi.org/10.1111/acel.12594
Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ et al. Age-related decline in BubR1 impairs adult hippocampal neurogenesis. Aging Cell. 2017 Jun 1;16(3):598-601. https://doi.org/10.1111/acel.12594
Yang, Zhongxi ; Jun, Heechul ; Choi, Chan Ii ; Yoo, Ki Hyun ; Cho, Chang Hoon ; Hussaini, Syed Mohammed Qasim ; Simmons, Ambrosia J. ; Kim, Seonhee ; Van Deursen, Jan ; Baker, Darren J ; Jang, Mi-Hyeon D. / Age-related decline in BubR1 impairs adult hippocampal neurogenesis. In: Aging Cell. 2017 ; Vol. 16, No. 3. pp. 598-601.
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