Age-related changes in astrocytic and ependymal cells of the subventricular zone

Vivian Capilla-Gonzalez, Arantxa Cebrian-Silla, Hugo Guerrero Cazares, Jose Manuel Garcia-Verdugo, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence.

Original languageEnglish (US)
Pages (from-to)790-803
Number of pages14
JournalGLIA
Volume62
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Neural Stem Cells
Lateral Ventricles
Intermediate Filaments
Neurogenesis
Brain
Population Dynamics
Nervous System Diseases
Inbred C57BL Mouse
Astrocytes
Thymidine
Population

Keywords

  • Aging
  • Astrocytes
  • Ependymal cells
  • Neural stem cells
  • Subventricular zone
  • Ultrastructure

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Age-related changes in astrocytic and ependymal cells of the subventricular zone. / Capilla-Gonzalez, Vivian; Cebrian-Silla, Arantxa; Guerrero Cazares, Hugo; Garcia-Verdugo, Jose Manuel; Quinones-Hinojosa, Alfredo.

In: GLIA, Vol. 62, No. 5, 2014, p. 790-803.

Research output: Contribution to journalArticle

Capilla-Gonzalez, Vivian ; Cebrian-Silla, Arantxa ; Guerrero Cazares, Hugo ; Garcia-Verdugo, Jose Manuel ; Quinones-Hinojosa, Alfredo. / Age-related changes in astrocytic and ependymal cells of the subventricular zone. In: GLIA. 2014 ; Vol. 62, No. 5. pp. 790-803.
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