Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B

the Hepatitis B Research Network (HBRN)

Research output: Contribution to journalArticle

Abstract

Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among those up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.

Original languageEnglish (US)
Pages (from-to)856-865
Number of pages10
JournalJournal of viral hepatitis
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Hepatitis B e Antigens
Chronic Hepatitis B
Genotype
Hepatitis B virus
Virus Diseases
Viremia
Natural History
Hepatitis B
Antiviral Agents
Hepatocellular Carcinoma
Cohort Studies
Cross-Sectional Studies
Demography

Keywords

  • e antigen
  • hepatitis B
  • natural history

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

Cite this

Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. / the Hepatitis B Research Network (HBRN).

In: Journal of viral hepatitis, Vol. 26, No. 7, 01.07.2019, p. 856-865.

Research output: Contribution to journalArticle

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abstract = "Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37{\%}) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85{\%} among those up to 10 years of age to only 12{\%} among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.",
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AU - the Hepatitis B Research Network (HBRN)

AU - Di Bisceglie, Adrian M.

AU - King, Wendy C.

AU - Lisker-Melman, Mauricio

AU - Khalili, Mandana

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AU - Chung, Raymond T.

AU - Roberts, Lewis Rowland

AU - Hassan, Mohamed A.

AU - Sarah, J.

AU - Wong, David K.

AU - Juan, Joshua

AU - Yim, Colina

AU - Patel, Keyur

AU - Murakami, Carol S.

AU - Perrillo, Robert

AU - Rodriguez-Baez, Norberto

AU - Han, Steven Huy B.

AU - Geffen, David

AU - Tran, Tram T.

AU - Anna, S.

AU - Fontana, Robert J.

AU - Younoszai, Barak

AU - Fried, Michael W.

AU - Muir, Andrew

AU - Evon, Donna

AU - Darling, Jama M.

AU - Carithers, Robert C.

AU - Shuhart, Margaret

AU - Kowdley, Kris V.

AU - Wang, Chia C.

AU - Murray, Karen F.

AU - Luketic, Velimir A.

AU - Jake Liang, T.

AU - Hoofnagle, Jay H.

AU - Doo, Edward

AU - Chang, Kyong Mi

AU - Park, Jang June

AU - Wahed, Abdus

PY - 2019/7/1

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N2 - Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among those up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.

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KW - hepatitis B

KW - natural history

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