Age, family history, and memory and future risk for cognitive impairment

Research output: Contribution to journalArticle

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Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Clinical and Experimental Neuropsychology
Issue number1
StatePublished - Jan 2009



  • Cognitive decline
  • Dementia
  • Family history
  • Rey auditory verbal learning test
  • Risk

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

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