Age, family history, and memory and future risk for cognitive impairment

Dona E.C. Locke; Robert J. Ivnik; Ruth H. Cha; David S. Knopman; Eric G. Tangalos; Bradley F. Boeve; Ronald C. Petersen; Glenn E. Smith

doi:10.1080/13803390802020443

Age, family history, and memory and future risk for cognitive impairment

Dona E.C. Locke, Robert J. Ivnik, Ruth H. Cha, David S. Knopman, Eric G. Tangalos, Bradley F. Boeve, Ronald C. Petersen, Glenn E. Smith

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1080/13803390802020443
State	Published - Jan 2009

Keywords

Cognitive decline
Dementia
Family history
Rey auditory verbal learning test
Risk

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Clinical Psychology
Neurology
Clinical Neurology

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10.1080/13803390802020443

Cite this

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title = "Age, family history, and memory and future risk for cognitive impairment",

abstract = "Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.",

keywords = "Cognitive decline, Dementia, Family history, Rey auditory verbal learning test, Risk",

author = "Locke, {Dona E.C.} and Ivnik, {Robert J.} and Cha, {Ruth H.} and Knopman, {David S.} and Tangalos, {Eric G.} and Boeve, {Bradley F.} and Petersen, {Ronald C.} and Smith, {Glenn E.}",

note = "Funding Information: This research was supported by National Institute of Aging Grants P50 AG16574 and U01 AG06786, by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer{\textquoteright}s Disease Research Program and by the Mayo Foundation. There are no conflicts of interest for any author relevant to the subject matter or materials discussed in the manuscript.",

year = "2009",

month = jan,

doi = "10.1080/13803390802020443",

language = "English (US)",

volume = "31",

pages = "111--116",

journal = "Journal of Clinical and Experimental Neuropsychology",

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AU - Locke, Dona E.C.

AU - Ivnik, Robert J.

AU - Cha, Ruth H.

AU - Knopman, David S.

AU - Tangalos, Eric G.

AU - Boeve, Bradley F.

AU - Petersen, Ronald C.

AU - Smith, Glenn E.

N1 - Funding Information: This research was supported by National Institute of Aging Grants P50 AG16574 and U01 AG06786, by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program and by the Mayo Foundation. There are no conflicts of interest for any author relevant to the subject matter or materials discussed in the manuscript.

PY - 2009/1

Y1 - 2009/1

N2 - Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.

AB - Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention. Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment. Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance. Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.

KW - Cognitive decline

KW - Dementia

KW - Family history

KW - Rey auditory verbal learning test

KW - Risk

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Age, family history, and memory and future risk for cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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