Age effect on albumin and fibrinogen synthesis in humans

Research output: Contribution to journalArticle

Abstract

We determined the effect of age on synthesis rates and concentrations of albumin and fibrinogen in 12 each of young (20-30 yrs), middle age (45-55) and elderly (>65) healthy subjects. We measured fractional synthesis rates (FSR) of these proteins using L[1- 13C]leucine and L[ 15N]Phenylalanine as tracers. While FSR of fibrinogen using both the tracers declined with age (Using Phenylalanine FSR for Young = 22.95 ± 3.3%/day, Middle = 17.28±1.3 and Old = 15.3 ±0.9; r 2= 0.16, P<0.05) the concentrations of fibrinogen increased with age (Young = 263±33 mg/100ml, Middle =368±27 and Old = 414± 25; r 2 = 0.30, P<0.001). Neither the FSR nor the plasma concentrations of albumin changed with age. These results indicate that while albumin synthesis rate is not affected by age fibrinogen synthesis rate declines with age, indicating a differential age-effect on synthesis of these two liver proteins. Although synthesis rate of fibrinogen decreased with age, the concentration fibrinogen increased with age, thus, indicating that it is the decrease in fibrinogen degradation that causes an age-related increase in fibrinogen concentration. This increased fibrinogen concentration may be a factor involved in the age related increase in thromboembolic episodes.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

fibrinogen
Fibrinogen
albumins
Albumins
synthesis
fractional synthesis rate
Phenylalanine
phenylalanine
tracer techniques
Serum Albumin
Leucine
liver protein
Liver
Healthy Volunteers
Proteins
leucine
Degradation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Age effect on albumin and fibrinogen synthesis in humans. / Fu, A. Z.; Nair, K Sreekumaran.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

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