Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Tim L. Emmerzaal; Richard J. Rodenburg; Heikki Tanila; Vivienne Verweij; Amanda J. Kiliaan; Tamas Kozicz

doi:10.3233/JAD-180337

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Tim L. Emmerzaal, Richard J. Rodenburg, Heikki Tanila, Vivienne Verweij, Amanda J. Kiliaan, Tamas Kozicz

Medical Genetics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Journal of Alzheimer's disease : JAD
Volume	66
Issue number	1
DOIs	https://doi.org/10.3233/JAD-180337
State	Published - 2018

Keywords

Alzheimer’s disease
amyloid beta-peptides
electron transport complex II
electron transport complex IV
mice
mitochondria

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-180337

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abstract = "Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.",

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AU - Verweij, Vivienne

AU - Kiliaan, Amanda J.

AU - Kozicz, Tamas

PY - 2018

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Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Abstract

Keywords

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