Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Tim L. Emmerzaal; Richard J. Rodenburg; Heikki Tanila; Vivienne Verweij; Amanda J. Kiliaan; Tamas Kozicz

doi:10.3233/JAD-180337

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Tim L. Emmerzaal, Richard J. Rodenburg, Heikki Tanila, Vivienne Verweij, Amanda J. Kiliaan, Tamas Kozicz

Medical Genetics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Journal of Alzheimer's disease : JAD
Volume	66
Issue number	1
DOIs	https://doi.org/10.3233/JAD-180337
State	Published - Jan 1 2018

Keywords

Alzheimer’s disease
amyloid beta-peptides
electron transport complex II
electron transport complex IV
mice
mitochondria

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

Access to Document

10.3233/JAD-180337

Cite this

@article{0975779f08d1468cbaac1d2a36b704d6,

title = "Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease",

abstract = "Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.",

keywords = "Alzheimer{\textquoteright}s disease, amyloid beta-peptides, electron transport complex II, electron transport complex IV, mice, mitochondria",

author = "Emmerzaal, {Tim L.} and Rodenburg, {Richard J.} and Heikki Tanila and Vivienne Verweij and Kiliaan, {Amanda J.} and Tamas Kozicz",

year = "2018",

month = jan,

day = "1",

doi = "10.3233/JAD-180337",

language = "English (US)",

volume = "66",

pages = "75--82",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "1",

}

TY - JOUR

T1 - Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

AU - Emmerzaal, Tim L.

AU - Rodenburg, Richard J.

AU - Tanila, Heikki

AU - Verweij, Vivienne

AU - Kiliaan, Amanda J.

AU - Kozicz, Tamas

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.

AB - Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model.

KW - Alzheimer’s disease

KW - amyloid beta-peptides

KW - electron transport complex II

KW - electron transport complex IV

KW - mice

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85055162304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055162304&partnerID=8YFLogxK

U2 - 10.3233/JAD-180337

DO - 10.3233/JAD-180337

M3 - Article

C2 - 30248054

AN - SCOPUS:85055162304

SN - 1387-2877

VL - 66

SP - 75

EP - 82

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this