Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

Young Pyo Kim; Hong Kim; Mal Soon Shin; Hyun Kyung Chang; Mi Hyeon Jang; Min Chul Shin; Sam Jun Lee; Hee Hyuk Lee; Jin Hwan Yoon; Ill Gyu Jeong; Chang Ju Kim

doi:10.1016/j.neulet.2003.11.005

Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

Young Pyo Kim, Hong Kim, Mal Soon Shin, Hyun Kyung Chang, Mi Hyeon Jang, Min Chul Shin, Sam Jun Lee, Hee Hyuk Lee, Jin Hwan Yoon, Ill Gyu Jeong, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2′-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.

Original language	English (US)
Pages (from-to)	152-154
Number of pages	3
Journal	Neuroscience Letters
Volume	355
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2003.11.005
State	Published - Jan 23 2004

Keywords

Age-dependence
Cell proliferation
Dentate gyrus
Immunohistochemistry
Treadmill exercise

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.11.005

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title = "Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats",

abstract = "The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2′-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.",

keywords = "Age-dependence, Cell proliferation, Dentate gyrus, Immunohistochemistry, Treadmill exercise",

author = "Kim, {Young Pyo} and Hong Kim and Shin, {Mal Soon} and Chang, {Hyun Kyung} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Sam Jun} and Lee, {Hee Hyuk} and Yoon, {Jin Hwan} and Jeong, {Ill Gyu} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2002-050-G00005).",

year = "2004",

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doi = "10.1016/j.neulet.2003.11.005",

language = "English (US)",

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pages = "152--154",

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AU - Kim, Young Pyo

AU - Kim, Hong

AU - Shin, Mal Soon

AU - Chang, Hyun Kyung

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Sam Jun

AU - Lee, Hee Hyuk

AU - Yoon, Jin Hwan

AU - Jeong, Ill Gyu

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2002-050-G00005).

PY - 2004/1/23

Y1 - 2004/1/23

N2 - The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2′-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.

AB - The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2′-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.

KW - Age-dependence

KW - Cell proliferation

KW - Dentate gyrus

KW - Immunohistochemistry

KW - Treadmill exercise

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Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

Abstract

Keywords

ASJC Scopus subject areas

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