Age at onset of inflammatory bowel disease and the risk of surgery for non-neoplastic bowel disease

W. J. Tremaine, L. J. Timmons, E. V. Loftus, D. S. Pardi, W. J. Sandborn, W. S. Harmsen, P. Thapa, A. R. Zinsmeister

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: There is conflicting data regarding the response to medical and surgical therapy for inflammatory bowel disease with respect to age at disease onset. Aim: To determine if the age at onset of Crohn's disease and ulcerative colitis is a risk factor for surgery for non-neoplastic bowel disease. Methods: This was a case-control study of patients evaluated between 1998 and 2001. Cases had undergone an initial operation for bowel disease. Controls were matched 1:1 for gender, disease subtype, date of first visit (±2 years), time from diagnosis prior to first visit (±3 years) and duration of follow-up. Association with age, disease extent, smoking history, medication use and co-morbidities vs. case/control status was assessed using multiple variable conditional logistic regression to estimate the odds ratio (OR) and 95% confidence intervals (CI) for undergoing surgery. Results: Among 132 Crohn's patients, older patients had lower odds for surgery (OR per 5 years, 0.86; 95% CI: 0.75-0.98). The rate of surgery for non-neoplastic bowel disease was not significantly associated with disease distribution, co-morbidities or cigarette smoking. Among 234 ulcerative colitis patients, the rate of surgery was unrelated to age, disease extent, co-morbidities or cigarette smoking, Conclusions: For Crohn's disease, but not ulcerative colitis, the risk of surgery for non-neoplastic bowel disease decreases with increasing age at diagnosis, irrespective of disease distribution and history of cigarette smoking.

Original languageEnglish (US)
Pages (from-to)1435-1441
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume25
Issue number12
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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    Tremaine, W. J., Timmons, L. J., Loftus, E. V., Pardi, D. S., Sandborn, W. J., Harmsen, W. S., Thapa, P., & Zinsmeister, A. R. (2007). Age at onset of inflammatory bowel disease and the risk of surgery for non-neoplastic bowel disease. Alimentary Pharmacology and Therapeutics, 25(12), 1435-1441. https://doi.org/10.1111/j.1365-2036.2007.03341.x