Age at last birth in relation to risk of endometrial cancer: Pooled analysis in the epidemiology of endometrial cancer consortium

Veronica Wendy Setiawan, Malcolm C. Pike, Stalo Karageorgi, Sandra L. Deming, Kristin Anderson, Leslie Bernstein, Louise A. Brinton, Hui Cai, James R. Cerhan, Wendy Cozen, Chu Chen, Jennifer Doherty, Jo L. Freudenheim, Marc T. Goodman, Susan E. Hankinson, James V. Lacey, Xiaolin Liang, Jolanta Lissowska, Lingeng Lu, Galina LurieThomas MacK, Rayna K. Matsuno, Susan McCann, Kirsten B. Moysich, Sara H. Olson, Radhai Rastogi, Timothy R. Rebbeck, Harvey Risch, Kim Robien, Catherine Schairer, Xiao Ou Shu, Amanda B. Spurdle, Brian L. Strom, Pamela J. Thompson, Giske Ursin, Penelope M. Webb, Noel S. Weiss, Nicolas Wentzensen, Yong Bing Xiang, Hannah P. Yang, Herbert Yu, Pamela L. Horn-Ross, Immaculata De Vivo

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (Ptrend < 0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95 confidence interval: 0.85, 0.90). Women who last gave birth at 40 years of age or older had a 44 decreased risk compared with women who had their last birth under the age of 25 years (95 confidence interval: 47, 66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalAmerican journal of epidemiology
Volume176
Issue number4
DOIs
StatePublished - Aug 15 2012

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Keywords

  • endometrial neoplasms
  • parity
  • reproductive history

ASJC Scopus subject areas

  • Epidemiology

Cite this

Setiawan, V. W., Pike, M. C., Karageorgi, S., Deming, S. L., Anderson, K., Bernstein, L., Brinton, L. A., Cai, H., Cerhan, J. R., Cozen, W., Chen, C., Doherty, J., Freudenheim, J. L., Goodman, M. T., Hankinson, S. E., Lacey, J. V., Liang, X., Lissowska, J., Lu, L., ... De Vivo, I. (2012). Age at last birth in relation to risk of endometrial cancer: Pooled analysis in the epidemiology of endometrial cancer consortium. American journal of epidemiology, 176(4), 269-278. https://doi.org/10.1093/aje/kws129