Age-associated inflammation inhibits epidermal stem cell function

Jason Doles, Mekayla Storer, Luca Cozzuto, Guglielmo Roma, William M. Keyes

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.

Original languageEnglish (US)
Pages (from-to)2144-2153
Number of pages10
JournalGenes and Development
Volume26
Issue number19
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

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Stem Cells
Inflammation
Homeostasis
Cytokines
Skin Aging
High-Throughput Nucleotide Sequencing
Hair Follicle
Epidermis
Neoplasms

Keywords

  • Aging
  • Epidermis
  • Jak-Stat
  • Stem cells

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Age-associated inflammation inhibits epidermal stem cell function. / Doles, Jason; Storer, Mekayla; Cozzuto, Luca; Roma, Guglielmo; Keyes, William M.

In: Genes and Development, Vol. 26, No. 19, 01.10.2012, p. 2144-2153.

Research output: Contribution to journalArticle

Doles, J, Storer, M, Cozzuto, L, Roma, G & Keyes, WM 2012, 'Age-associated inflammation inhibits epidermal stem cell function', Genes and Development, vol. 26, no. 19, pp. 2144-2153. https://doi.org/10.1101/gad.192294.112
Doles, Jason ; Storer, Mekayla ; Cozzuto, Luca ; Roma, Guglielmo ; Keyes, William M. / Age-associated inflammation inhibits epidermal stem cell function. In: Genes and Development. 2012 ; Vol. 26, No. 19. pp. 2144-2153.
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