Age- and sex-related atrial electrophysiologic and structural changes

Xiao Ke Liu; Arshad Jahangir; Andre Terzic; Bernard J. Gersh; Stephen C. Hammill; Win Kuang Shen

doi:10.1016/j.amjcard.2004.04.040

Age- and sex-related atrial electrophysiologic and structural changes

Xiao Ke Liu, Arshad Jahangir, Andre Terzic, Bernard J. Gersh, Stephen C. Hammill, Win Kuang Shen

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Age and gender dependence of the 3 major variables - left atrial (LA) dimension, effective refractory period (ERP), and atrial conduction - that govern the development of atrial fibrillation (AF) were examined in 76 women and 39 men without structural heart disease. A significant positive correlation was found between age and LA dimension, mainly because of a strongly positive correlation in women not taking hormone replacement therapy but not in women on hormone replacement therapy. Men had a significantly greater average LA dimension than women. Neither ERP nor atrial conduction estimated by normalized P-wave duration demonstrated any significant correlation with either age or gender. It was concluded that LA size is greater in the elderly and in men, which may increase their risk for AF.

Original language	English (US)
Pages (from-to)	373-375
Number of pages	3
Journal	American Journal of Cardiology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/j.amjcard.2004.04.040
State	Published - Aug 1 2004

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.04.040

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title = "Age- and sex-related atrial electrophysiologic and structural changes",

abstract = "Age and gender dependence of the 3 major variables - left atrial (LA) dimension, effective refractory period (ERP), and atrial conduction - that govern the development of atrial fibrillation (AF) were examined in 76 women and 39 men without structural heart disease. A significant positive correlation was found between age and LA dimension, mainly because of a strongly positive correlation in women not taking hormone replacement therapy but not in women on hormone replacement therapy. Men had a significantly greater average LA dimension than women. Neither ERP nor atrial conduction estimated by normalized P-wave duration demonstrated any significant correlation with either age or gender. It was concluded that LA size is greater in the elderly and in men, which may increase their risk for AF.",

author = "Liu, {Xiao Ke} and Arshad Jahangir and Andre Terzic and Gersh, {Bernard J.} and Hammill, {Stephen C.} and Shen, {Win Kuang}",

note = "Funding Information: Dr. Jahangir is supported by the National Institute on Aging (R01 AG21201-01), Bethesda, Maryland; the American Heart Association (National Scientist Development Grant), Dallas, Texas; and the Mayo Foundation (CR75 Research Award), Rochester, Minnesota. Dr. Terzic is supported by the National Institutes of Health, Bethesda, Maryland; the American Heart Association; the Marriott Foundation for People With Disabilities, Washington, DC; the Miami Heart Research Institute, Miami Beach, Florida; the Bruce and Ruth Rappaport Program in Vascular Biology; and the Mayo Foundation Clinician-Investigator Program. ",

year = "2004",

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doi = "10.1016/j.amjcard.2004.04.040",

language = "English (US)",

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T1 - Age- and sex-related atrial electrophysiologic and structural changes

AU - Liu, Xiao Ke

AU - Jahangir, Arshad

AU - Terzic, Andre

AU - Gersh, Bernard J.

AU - Hammill, Stephen C.

AU - Shen, Win Kuang

N1 - Funding Information: Dr. Jahangir is supported by the National Institute on Aging (R01 AG21201-01), Bethesda, Maryland; the American Heart Association (National Scientist Development Grant), Dallas, Texas; and the Mayo Foundation (CR75 Research Award), Rochester, Minnesota. Dr. Terzic is supported by the National Institutes of Health, Bethesda, Maryland; the American Heart Association; the Marriott Foundation for People With Disabilities, Washington, DC; the Miami Heart Research Institute, Miami Beach, Florida; the Bruce and Ruth Rappaport Program in Vascular Biology; and the Mayo Foundation Clinician-Investigator Program.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Age and gender dependence of the 3 major variables - left atrial (LA) dimension, effective refractory period (ERP), and atrial conduction - that govern the development of atrial fibrillation (AF) were examined in 76 women and 39 men without structural heart disease. A significant positive correlation was found between age and LA dimension, mainly because of a strongly positive correlation in women not taking hormone replacement therapy but not in women on hormone replacement therapy. Men had a significantly greater average LA dimension than women. Neither ERP nor atrial conduction estimated by normalized P-wave duration demonstrated any significant correlation with either age or gender. It was concluded that LA size is greater in the elderly and in men, which may increase their risk for AF.

AB - Age and gender dependence of the 3 major variables - left atrial (LA) dimension, effective refractory period (ERP), and atrial conduction - that govern the development of atrial fibrillation (AF) were examined in 76 women and 39 men without structural heart disease. A significant positive correlation was found between age and LA dimension, mainly because of a strongly positive correlation in women not taking hormone replacement therapy but not in women on hormone replacement therapy. Men had a significantly greater average LA dimension than women. Neither ERP nor atrial conduction estimated by normalized P-wave duration demonstrated any significant correlation with either age or gender. It was concluded that LA size is greater in the elderly and in men, which may increase their risk for AF.

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Age- and sex-related atrial electrophysiologic and structural changes

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ASJC Scopus subject areas

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