Age and sex patterns of drug prescribing in a defined American population

Wenjun Zhong, Hilal D Maradit Kremers, Jennifer St. Sauver, Barbara P. Yawn, Jon Owen Ebbert, Veronique Lee Roger, Debra J. Jacobson, Michaela E. McGree, Scott M. Brue, Walter A Rocca

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objective: To describe the age and sex patterns of drug prescribing in Olmsted County, Minnesota. Patients and Methods: Population-based drug prescription records for the Olmsted County population in 2009 were obtained using the Rochester Epidemiology Project medical records linkage system (n=142,377). Drug prescriptions were classified using RxNorm codes and were grouped using the National Drug File - Reference Terminology. Results: Overall, 68.1% of the population (n=96,953) received a prescription from at least 1 drug group, 51.6% (n=73,501) received prescriptions from 2 or more groups, and 21.2% (n=30,218) received prescriptions from 5 or more groups. The most commonly prescribed drug groups in the entire population were penicillins and β-lactam antimicrobials (17%; n=23,734), antidepressants (13%; n=18,028), opioid analgesics (12%; n=16,954), antilipemic agents (11%; n=16,082), and vaccines/toxoids (11%; n=15,918). However, prescribing patterns differed by age and sex. Vaccines/toxoids, penicillins and β-lactam antimicrobials, and antiasthmatic drugs were most commonly prescribed in persons younger than 19 years. Antidepressants and opioid analgesics were most commonly prescribed in young andmiddle-aged adults. Cardiovascular drugs were most commonly prescribed in older adults. Women received more prescriptions than men for several drug groups, in particular for antidepressants. For several drug groups, use increased with advancing age. Conclusion: This study provides valuable baseline information for future studies of drug utilization and drug-related outcomes in this population.

Original languageEnglish (US)
Pages (from-to)697-707
Number of pages11
JournalMayo Clinic Proceedings
Volume88
Issue number7
DOIs
StatePublished - Jul 2013

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Drug Prescriptions
Prescriptions
Pharmaceutical Preparations
Toxoids
Antidepressive Agents
Population
Lactams
RxNorm
Penicillins
Opioid Analgesics
Medical Record Linkage
Vaccines
Anti-Asthmatic Agents
Drug Utilization
Hypolipidemic Agents
Cardiovascular Agents
Terminology
Epidemiology

ASJC Scopus subject areas

  • Medicine(all)

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Age and sex patterns of drug prescribing in a defined American population. / Zhong, Wenjun; Maradit Kremers, Hilal D; St. Sauver, Jennifer; Yawn, Barbara P.; Ebbert, Jon Owen; Roger, Veronique Lee; Jacobson, Debra J.; McGree, Michaela E.; Brue, Scott M.; Rocca, Walter A.

In: Mayo Clinic Proceedings, Vol. 88, No. 7, 07.2013, p. 697-707.

Research output: Contribution to journalArticle

Zhong, Wenjun ; Maradit Kremers, Hilal D ; St. Sauver, Jennifer ; Yawn, Barbara P. ; Ebbert, Jon Owen ; Roger, Veronique Lee ; Jacobson, Debra J. ; McGree, Michaela E. ; Brue, Scott M. ; Rocca, Walter A. / Age and sex patterns of drug prescribing in a defined American population. In: Mayo Clinic Proceedings. 2013 ; Vol. 88, No. 7. pp. 697-707.
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abstract = "Objective: To describe the age and sex patterns of drug prescribing in Olmsted County, Minnesota. Patients and Methods: Population-based drug prescription records for the Olmsted County population in 2009 were obtained using the Rochester Epidemiology Project medical records linkage system (n=142,377). Drug prescriptions were classified using RxNorm codes and were grouped using the National Drug File - Reference Terminology. Results: Overall, 68.1{\%} of the population (n=96,953) received a prescription from at least 1 drug group, 51.6{\%} (n=73,501) received prescriptions from 2 or more groups, and 21.2{\%} (n=30,218) received prescriptions from 5 or more groups. The most commonly prescribed drug groups in the entire population were penicillins and β-lactam antimicrobials (17{\%}; n=23,734), antidepressants (13{\%}; n=18,028), opioid analgesics (12{\%}; n=16,954), antilipemic agents (11{\%}; n=16,082), and vaccines/toxoids (11{\%}; n=15,918). However, prescribing patterns differed by age and sex. Vaccines/toxoids, penicillins and β-lactam antimicrobials, and antiasthmatic drugs were most commonly prescribed in persons younger than 19 years. Antidepressants and opioid analgesics were most commonly prescribed in young andmiddle-aged adults. Cardiovascular drugs were most commonly prescribed in older adults. Women received more prescriptions than men for several drug groups, in particular for antidepressants. For several drug groups, use increased with advancing age. Conclusion: This study provides valuable baseline information for future studies of drug utilization and drug-related outcomes in this population.",
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AU - Zhong, Wenjun

AU - Maradit Kremers, Hilal D

AU - St. Sauver, Jennifer

AU - Yawn, Barbara P.

AU - Ebbert, Jon Owen

AU - Roger, Veronique Lee

AU - Jacobson, Debra J.

AU - McGree, Michaela E.

AU - Brue, Scott M.

AU - Rocca, Walter A

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N2 - Objective: To describe the age and sex patterns of drug prescribing in Olmsted County, Minnesota. Patients and Methods: Population-based drug prescription records for the Olmsted County population in 2009 were obtained using the Rochester Epidemiology Project medical records linkage system (n=142,377). Drug prescriptions were classified using RxNorm codes and were grouped using the National Drug File - Reference Terminology. Results: Overall, 68.1% of the population (n=96,953) received a prescription from at least 1 drug group, 51.6% (n=73,501) received prescriptions from 2 or more groups, and 21.2% (n=30,218) received prescriptions from 5 or more groups. The most commonly prescribed drug groups in the entire population were penicillins and β-lactam antimicrobials (17%; n=23,734), antidepressants (13%; n=18,028), opioid analgesics (12%; n=16,954), antilipemic agents (11%; n=16,082), and vaccines/toxoids (11%; n=15,918). However, prescribing patterns differed by age and sex. Vaccines/toxoids, penicillins and β-lactam antimicrobials, and antiasthmatic drugs were most commonly prescribed in persons younger than 19 years. Antidepressants and opioid analgesics were most commonly prescribed in young andmiddle-aged adults. Cardiovascular drugs were most commonly prescribed in older adults. Women received more prescriptions than men for several drug groups, in particular for antidepressants. For several drug groups, use increased with advancing age. Conclusion: This study provides valuable baseline information for future studies of drug utilization and drug-related outcomes in this population.

AB - Objective: To describe the age and sex patterns of drug prescribing in Olmsted County, Minnesota. Patients and Methods: Population-based drug prescription records for the Olmsted County population in 2009 were obtained using the Rochester Epidemiology Project medical records linkage system (n=142,377). Drug prescriptions were classified using RxNorm codes and were grouped using the National Drug File - Reference Terminology. Results: Overall, 68.1% of the population (n=96,953) received a prescription from at least 1 drug group, 51.6% (n=73,501) received prescriptions from 2 or more groups, and 21.2% (n=30,218) received prescriptions from 5 or more groups. The most commonly prescribed drug groups in the entire population were penicillins and β-lactam antimicrobials (17%; n=23,734), antidepressants (13%; n=18,028), opioid analgesics (12%; n=16,954), antilipemic agents (11%; n=16,082), and vaccines/toxoids (11%; n=15,918). However, prescribing patterns differed by age and sex. Vaccines/toxoids, penicillins and β-lactam antimicrobials, and antiasthmatic drugs were most commonly prescribed in persons younger than 19 years. Antidepressants and opioid analgesics were most commonly prescribed in young andmiddle-aged adults. Cardiovascular drugs were most commonly prescribed in older adults. Women received more prescriptions than men for several drug groups, in particular for antidepressants. For several drug groups, use increased with advancing age. Conclusion: This study provides valuable baseline information for future studies of drug utilization and drug-related outcomes in this population.

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