Age and age-related diseases

Role of inflammation triggers and cytokines

Irene Maeve Rea, David S. Gibson, Victoria McGilligan, Susan E. McNerlan, H. Denis Alexander, Owen A Ross

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging. This reshaping of cytokine expression pattern, with a progressive tendency toward a pro-inflammatory phenotype has been called "inflamm-aging." Despite research there is no clear understanding about the causes of "inflamm-aging" that underpin most major age-related diseases, including atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer, and aging itself. While inflammation is part of the normal repair response for healing, and essential in keeping us safe from bacterial and viral infections and noxious environmental agents, not all inflammation is good. When inflammation becomes prolonged and persists, it can become damaging and destructive. Several common molecular pathways have been identified that are associated with both aging and low-grade inflammation. The age-related change in redox balance, the increase in age-related senescent cells, the senescence-associated secretory phenotype (SASP) and the decline in effective autophagy that can trigger the inflammasome, suggest that it may be possible to delay age-related diseases and aging itself by suppressing pro-inflammatory molecular mechanisms or improving the timely resolution of inflammation. Conversely there may be learning from molecular or genetic pathways from long-lived cohorts who exemplify good quality aging. Here, we will discuss some of the current ideas and highlight molecular pathways that appear to contribute to the immune imbalance and the cytokine dysregulation, which is associated with "inflammageing" or parainflammation. Evidence of these findings will be drawn from research in cardiovascular disease, cancer, neurological inflammation and rheumatoid arthritis.

Original languageEnglish (US)
Article number586
JournalFrontiers in Immunology
Volume9
Issue numberAPR
DOIs
StatePublished - Apr 9 2018

Fingerprint

Cytokines
Inflammation
Rheumatoid Arthritis
Inflammasomes
Phenotype
Cell Aging
Autophagy
Virus Diseases
Research
Bacterial Infections
Oxidation-Reduction
Molecular Biology
Immune System
Neoplasms
Atherosclerosis
Alzheimer Disease
Cardiovascular Diseases
Learning

Keywords

  • Age-related diseases
  • Aging
  • Autophagy
  • Cytokine dysregulation
  • Inflamm-aging
  • Inflammation resolution
  • Redox
  • SASP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Denis Alexander, H., & Ross, O. A. (2018). Age and age-related diseases: Role of inflammation triggers and cytokines. Frontiers in Immunology, 9(APR), [586]. https://doi.org/10.3389/fimmu.2018.00586

Age and age-related diseases : Role of inflammation triggers and cytokines. / Rea, Irene Maeve; Gibson, David S.; McGilligan, Victoria; McNerlan, Susan E.; Denis Alexander, H.; Ross, Owen A.

In: Frontiers in Immunology, Vol. 9, No. APR, 586, 09.04.2018.

Research output: Contribution to journalReview article

Rea, IM, Gibson, DS, McGilligan, V, McNerlan, SE, Denis Alexander, H & Ross, OA 2018, 'Age and age-related diseases: Role of inflammation triggers and cytokines', Frontiers in Immunology, vol. 9, no. APR, 586. https://doi.org/10.3389/fimmu.2018.00586
Rea, Irene Maeve ; Gibson, David S. ; McGilligan, Victoria ; McNerlan, Susan E. ; Denis Alexander, H. ; Ross, Owen A. / Age and age-related diseases : Role of inflammation triggers and cytokines. In: Frontiers in Immunology. 2018 ; Vol. 9, No. APR.
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