Affinity and enzyme-based biosensors: Recent advances and emerging applications in cell analysis and point-of-care testing

Ying Liu, Zimple Matharu, Michael C. Howland, Alexander Revzin, Aleksandr L. Simonian

Research output: Contribution to journalReview article

49 Scopus citations


The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to "frontline" physicians and nurses, and to obtain more precise information more quickly about the health status of a patient. This article gives an overview of recent advances in the field of biosensors, focusing on biosensors based on enzymes, aptamers, antibodies, and phages. In addition, this article attempts to describe efforts to apply these biosensors to clinical testing and cell analysis.

Original languageEnglish (US)
Pages (from-to)1181-1196
Number of pages16
JournalAnalytical and bioanalytical chemistry
Issue number4
StatePublished - Sep 1 2012



  • Aptamers
  • Biosensor
  • Enzyme
  • Phage
  • Point of care

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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