Adversomics: A new paradigm for vaccine safety and design

Jennifer A. Whitaker, Inna G. Ovsyannikova, Gregory A. Poland

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Despite the enormous population benefits of routine vaccination, vaccine adverse events (AEs) and reactions, whether real or perceived, have posed one of the greatest barriers to vaccine acceptance-and thus to infectious disease prevention-worldwide. A truly integrated clinical, translational, and basic science approach is required to understand the mechanisms behind vaccine AEs, predict them, and then apply this knowledge to new vaccine design approaches that decrease, or avoid, these events. The term 'adversomics' was first introduced in 2009 and refers to the study of vaccine adverse reactions using immunogenomics and systems biology approaches. In this review, we present the current state of adversomics research, review known associations and mechanisms of vaccine AEs/reactions, and outline a plan for the further development of this emerging research field.

Original languageEnglish (US)
Pages (from-to)935-947
Number of pages13
JournalExpert Review of Vaccines
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2015

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Keywords

  • drug-related side effects and adverse reactions
  • genetic association studies
  • genomics
  • immunogenetics
  • individualized medicine
  • polymorphism
  • single nucleotide
  • systems biology
  • vaccination
  • vaccines
  • viral vaccines

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

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