Adverse gastrointestinal effects of NSAIDs

Consequences and costs

Michelle Bidaut-Russell, Sherine E. Gabriel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most widely consumed medications. They are available by prescription and 'over the counter'. The same pharmacological properties which make them effective in the treatment of a variety of painful and/or arthritic conditions are responsible for a variety of adverse gastrointestinal effects, ranging from relatively mild dyspepsia to potentially lethal gastrointestinal (G1) bleeding and perforated ulcers. Yearly medical costs of G1 complications associated with the use of NSAIDs are very high and likely to increase with the growth of the ageing US population. A review of the literature (1970-2000) on consequences and costs of NSAID-associated G1 adverse effects, including iatrogenic cost factors of NSAIDs, was performed. The results were tabulated and compared. Knowledge and comparison of the consequences and costs of NSAID-associated G1 adverse effects in various populations and across various health care systems are important for clinical care, pharmacoeconomics and policy arenas.

Original languageEnglish (US)
Pages (from-to)739-753
Number of pages15
JournalBest Practice and Research: Clinical Gastroenterology
Volume15
Issue number5
DOIs
StatePublished - 2001

Fingerprint

Drug Costs
Anti-Inflammatory Agents
Costs and Cost Analysis
Pharmaceutical Preparations
Pharmaceutical Economics
Dyspepsia
Population
Ulcer
Arthritis
Prescriptions
Pharmacology
Hemorrhage
Delivery of Health Care
Growth

Keywords

  • Anti-inflammatory agents
  • Costs and cost analysis
  • Gastrointestinal diseases
  • Iatrogenic disease
  • Non-steroidal
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Adverse gastrointestinal effects of NSAIDs : Consequences and costs. / Bidaut-Russell, Michelle; Gabriel, Sherine E.

In: Best Practice and Research: Clinical Gastroenterology, Vol. 15, No. 5, 2001, p. 739-753.

Research output: Contribution to journalArticle

Bidaut-Russell, Michelle ; Gabriel, Sherine E. / Adverse gastrointestinal effects of NSAIDs : Consequences and costs. In: Best Practice and Research: Clinical Gastroenterology. 2001 ; Vol. 15, No. 5. pp. 739-753.
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