Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most widely consumed medications. They are available by prescription and 'over the counter'. The same pharmacological properties which make them effective in the treatment of a variety of painful and/or arthritic conditions are responsible for a variety of adverse gastrointestinal effects, ranging from relatively mild dyspepsia to potentially lethal gastrointestinal (G1) bleeding and perforated ulcers. Yearly medical costs of G1 complications associated with the use of NSAIDs are very high and likely to increase with the growth of the ageing US population. A review of the literature (1970-2000) on consequences and costs of NSAID-associated G1 adverse effects, including iatrogenic cost factors of NSAIDs, was performed. The results were tabulated and compared. Knowledge and comparison of the consequences and costs of NSAID-associated G1 adverse effects in various populations and across various health care systems are important for clinical care, pharmacoeconomics and policy arenas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 739-753 |
| Number of pages | 15 |
| Journal | Best Practice and Research: Clinical Gastroenterology |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Anti-inflammatory agents
- Costs and cost analysis
- Gastrointestinal diseases
- Iatrogenic disease
- Non-steroidal
- Peptic ulcer
ASJC Scopus subject areas
- Gastroenterology
Cite this
Adverse gastrointestinal effects of NSAIDs : Consequences and costs. / Bidaut-Russell, Michelle; Gabriel, Sherine E.
In: Best Practice and Research: Clinical Gastroenterology, Vol. 15, No. 5, 2001, p. 739-753.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adverse gastrointestinal effects of NSAIDs
T2 - Consequences and costs
AU - Bidaut-Russell, Michelle
AU - Gabriel, Sherine E.
PY - 2001
Y1 - 2001
N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most widely consumed medications. They are available by prescription and 'over the counter'. The same pharmacological properties which make them effective in the treatment of a variety of painful and/or arthritic conditions are responsible for a variety of adverse gastrointestinal effects, ranging from relatively mild dyspepsia to potentially lethal gastrointestinal (G1) bleeding and perforated ulcers. Yearly medical costs of G1 complications associated with the use of NSAIDs are very high and likely to increase with the growth of the ageing US population. A review of the literature (1970-2000) on consequences and costs of NSAID-associated G1 adverse effects, including iatrogenic cost factors of NSAIDs, was performed. The results were tabulated and compared. Knowledge and comparison of the consequences and costs of NSAID-associated G1 adverse effects in various populations and across various health care systems are important for clinical care, pharmacoeconomics and policy arenas.
AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most widely consumed medications. They are available by prescription and 'over the counter'. The same pharmacological properties which make them effective in the treatment of a variety of painful and/or arthritic conditions are responsible for a variety of adverse gastrointestinal effects, ranging from relatively mild dyspepsia to potentially lethal gastrointestinal (G1) bleeding and perforated ulcers. Yearly medical costs of G1 complications associated with the use of NSAIDs are very high and likely to increase with the growth of the ageing US population. A review of the literature (1970-2000) on consequences and costs of NSAID-associated G1 adverse effects, including iatrogenic cost factors of NSAIDs, was performed. The results were tabulated and compared. Knowledge and comparison of the consequences and costs of NSAID-associated G1 adverse effects in various populations and across various health care systems are important for clinical care, pharmacoeconomics and policy arenas.
KW - Anti-inflammatory agents
KW - Costs and cost analysis
KW - Gastrointestinal diseases
KW - Iatrogenic disease
KW - Non-steroidal
KW - Peptic ulcer
UR - http://www.scopus.com/inward/record.url?scp=0034756964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034756964&partnerID=8YFLogxK
U2 - 10.1053/bega.2001.0232
DO - 10.1053/bega.2001.0232
M3 - Article
VL - 15
SP - 739
EP - 753
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
SN - 1521-6918
IS - 5
ER -