Advancing the study of stroke in women: Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group

Cheryl D. Bushnell, Patricia Hurn, Carol Colton, Virginia M Miller, Gregory Del Zoppo, Mitchell S V Elkind, Barney Stern, David Herrington, Gwendolyn Ford-Lynch, Philip Gorelick, Andra James, Candice M. Brown, Emily Choi, Paul Bray, L. Kristin Newby, Larry B. Goldstein, James Simpkins

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.

Original languageEnglish (US)
Pages (from-to)2387-2399
Number of pages13
JournalStroke
Volume37
Issue number9
DOIs
StatePublished - Sep 2006

Fingerprint

National Institute of Neurological Disorders and Stroke
Stroke
Estrogens
Estrogen Replacement Therapy
Women's Health
Hemostasis
Neuroglia
Thrombosis
Endothelial Cells
Clinical Trials
Hormones
Inflammation
Education
Neurons
Pregnancy
Therapeutics
Research

Keywords

  • Estrogen
  • Minority groups
  • Stroke
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Advancing the study of stroke in women : Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group. / Bushnell, Cheryl D.; Hurn, Patricia; Colton, Carol; Miller, Virginia M; Del Zoppo, Gregory; Elkind, Mitchell S V; Stern, Barney; Herrington, David; Ford-Lynch, Gwendolyn; Gorelick, Philip; James, Andra; Brown, Candice M.; Choi, Emily; Bray, Paul; Newby, L. Kristin; Goldstein, Larry B.; Simpkins, James.

In: Stroke, Vol. 37, No. 9, 09.2006, p. 2387-2399.

Research output: Contribution to journalArticle

Bushnell, CD, Hurn, P, Colton, C, Miller, VM, Del Zoppo, G, Elkind, MSV, Stern, B, Herrington, D, Ford-Lynch, G, Gorelick, P, James, A, Brown, CM, Choi, E, Bray, P, Newby, LK, Goldstein, LB & Simpkins, J 2006, 'Advancing the study of stroke in women: Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group', Stroke, vol. 37, no. 9, pp. 2387-2399. https://doi.org/10.1161/01.STR.0000236053.37695.15
Bushnell, Cheryl D. ; Hurn, Patricia ; Colton, Carol ; Miller, Virginia M ; Del Zoppo, Gregory ; Elkind, Mitchell S V ; Stern, Barney ; Herrington, David ; Ford-Lynch, Gwendolyn ; Gorelick, Philip ; James, Andra ; Brown, Candice M. ; Choi, Emily ; Bray, Paul ; Newby, L. Kristin ; Goldstein, Larry B. ; Simpkins, James. / Advancing the study of stroke in women : Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group. In: Stroke. 2006 ; Vol. 37, No. 9. pp. 2387-2399.
@article{4e328a8aa5494514903d89819906b5a6,
title = "Advancing the study of stroke in women: Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group",
abstract = "BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.",
keywords = "Estrogen, Minority groups, Stroke, Women",
author = "Bushnell, {Cheryl D.} and Patricia Hurn and Carol Colton and Miller, {Virginia M} and {Del Zoppo}, Gregory and Elkind, {Mitchell S V} and Barney Stern and David Herrington and Gwendolyn Ford-Lynch and Philip Gorelick and Andra James and Brown, {Candice M.} and Emily Choi and Paul Bray and Newby, {L. Kristin} and Goldstein, {Larry B.} and James Simpkins",
year = "2006",
month = "9",
doi = "10.1161/01.STR.0000236053.37695.15",
language = "English (US)",
volume = "37",
pages = "2387--2399",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Advancing the study of stroke in women

T2 - Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group

AU - Bushnell, Cheryl D.

AU - Hurn, Patricia

AU - Colton, Carol

AU - Miller, Virginia M

AU - Del Zoppo, Gregory

AU - Elkind, Mitchell S V

AU - Stern, Barney

AU - Herrington, David

AU - Ford-Lynch, Gwendolyn

AU - Gorelick, Philip

AU - James, Andra

AU - Brown, Candice M.

AU - Choi, Emily

AU - Bray, Paul

AU - Newby, L. Kristin

AU - Goldstein, Larry B.

AU - Simpkins, James

PY - 2006/9

Y1 - 2006/9

N2 - BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.

AB - BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.

KW - Estrogen

KW - Minority groups

KW - Stroke

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=33748355616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748355616&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000236053.37695.15

DO - 10.1161/01.STR.0000236053.37695.15

M3 - Article

C2 - 16857945

AN - SCOPUS:33748355616

VL - 37

SP - 2387

EP - 2399

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 9

ER -