Advancing the study of stroke in women: Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group

Cheryl D. Bushnell, Patricia Hurn, Carol Colton, Virginia M. Miller, Gregory Del Zoppo, Mitchell S.V. Elkind, Barney Stern, David Herrington, Gwendolyn Ford-Lynch, Philip Gorelick, Andra James, Candice M. Brown, Emily Choi, Paul Bray, L. Kristin Newby, Larry B. Goldstein, James Simpkins

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.

Original languageEnglish (US)
Pages (from-to)2387-2399
Number of pages13
JournalStroke
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2006

    Fingerprint

Keywords

  • Estrogen
  • Minority groups
  • Stroke
  • Women

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Bushnell, C. D., Hurn, P., Colton, C., Miller, V. M., Del Zoppo, G., Elkind, M. S. V., Stern, B., Herrington, D., Ford-Lynch, G., Gorelick, P., James, A., Brown, C. M., Choi, E., Bray, P., Newby, L. K., Goldstein, L. B., & Simpkins, J. (2006). Advancing the study of stroke in women: Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group. Stroke, 37(9), 2387-2399. https://doi.org/10.1161/01.STR.0000236053.37695.15