Advances in the vaccination of the elderly against influenza: Role of a high-dose vaccine

Seth J. Sullivan, Robert Jacobson, Gregory A. Poland

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

On 23 December 2009, the US FDA approved Fluzone® High Dose, a high-dose formulation of the trivalent inactivated influenza vaccine, for prevention of influenza in people 65 years of age and older. As it was approved via an accelerated process designed to allow expeditious availability of safe and effective products with promise to treat or prevent serious or life-threatening diseases, the manufacturer is required to conduct further studies to demonstrate effectiveness. Although these studies are underway, a recently completed randomized, controlled trial demonstrated that this vaccine, containing four-times more hemagglutinin than standard-dose inactivated influenza vaccines, can produce an enhanced immunologic response in subjects of 65 years of age and older, while maintaining a favorable safety profile. This article introduces the vaccine, presents currently available safety and immunogenicity data, discusses current recommendations for use, and proposes what we can expect in the coming years.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalExpert review of vaccines
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2010

Keywords

  • active immunization
  • aged
  • aging
  • human
  • immune system
  • immunization
  • immunosenescence
  • inactivated
  • influenza
  • influenza vaccine
  • vaccine
  • viral vaccine

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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