TY - JOUR
T1 - Advances in myeloma genetics and prospects for pharmacogenomic testing in multiple myeloma
AU - Claudio, Jaime O.
AU - Stewart, A. Keith
PY - 2005
Y1 - 2005
N2 - Pharmacogenomic studies in multiple myeloma, a neoplasia of clonally expanded malignant bone marrow plasma cells, are helping to set the stage for individualized therapy. Although relatively few in numbers, these studies are already providing new therapeutic targets and avenues for drug discoveries as well as contributing to novel prognostic markers in multiple myeloma. High-throughput mutation screening of the kinome promises to identify further novel targets for therapy. Genetics and gene expression profiling technology have improved molecular-based patient stratification and prognostic staging, expanded knowledge of the molecular mechanism of chemotherapeutic agents, and provided a better understanding of myeloma bone disease. The use of pharmacogenomic strategies in myeloma is thus already changing medical practice.
AB - Pharmacogenomic studies in multiple myeloma, a neoplasia of clonally expanded malignant bone marrow plasma cells, are helping to set the stage for individualized therapy. Although relatively few in numbers, these studies are already providing new therapeutic targets and avenues for drug discoveries as well as contributing to novel prognostic markers in multiple myeloma. High-throughput mutation screening of the kinome promises to identify further novel targets for therapy. Genetics and gene expression profiling technology have improved molecular-based patient stratification and prognostic staging, expanded knowledge of the molecular mechanism of chemotherapeutic agents, and provided a better understanding of myeloma bone disease. The use of pharmacogenomic strategies in myeloma is thus already changing medical practice.
UR - http://www.scopus.com/inward/record.url?scp=18744361878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18744361878&partnerID=8YFLogxK
U2 - 10.2165/00129785-200505010-00003
DO - 10.2165/00129785-200505010-00003
M3 - Review article
C2 - 15727487
AN - SCOPUS:18744361878
SN - 1175-2203
VL - 5
SP - 35
EP - 43
JO - American Journal of PharmacoGenomics
JF - American Journal of PharmacoGenomics
IS - 1
ER -