Advances in metanephrine testing for the diagnosis of pheochromocytoma

Research output: Contribution to journalReview article

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Abstract

Pheochromocytoma is a lethal tumor of chromaffin cells of the adrenal medulla that produces episodes of hypertension with the symptoms of palpitations, severe headaches, and sweating. The diagnosis of pheochromocytoma is a challenging one; autopsy series suggest that many pheochromocytomas are not clinically suspected, and the undiagnosed tumor can be associated with morbid consequences. The testing of catecholamines, metanephrines, and Vanillylymandelic acid commonly is used for screening of pheochromocytoma. The diagnostic value of various biochemical tests, as reported in recent Mayo and National Institutes of Health studies, have been compared and discussed in detail. The recent developments in the methodologies of metanephrines testing also are presented.

Original languageEnglish (US)
Pages (from-to)85-103
Number of pages19
JournalClinics in Laboratory Medicine
Volume24
Issue number1
DOIs
StatePublished - Mar 1 2004

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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