Advances in lupus genetics

Timothy B. Niewold

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose of review The field of systemic lupus erythematosus (SLE) genetics has been advancing rapidly in recent years. This review will summarize recent advances in SLE genetics. Recent findings Genome-wide-association and follow-up studies have greatly expanded the list of associated polymorphisms, and much current work strives to integrate these polymorphisms into immune system biology and the pathogenic mediators involved in the disease. This review covers some current areas of interest, including genetic studies in non-European SLE patient populations, studies of pathogenic immune system subphenotypes such as type I interferon and autoantibodies, and a rapidly growing body of work investigating the functional consequences of the genetic polymorphisms associated with SLE. Summary These studies provide a fascinating window into human SLE disease biology. As the work proceeds from genetic association signal to altered human biology, we move closer to tailoring interventions based upon an individuals genetic substrate.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalCurrent Opinion in Rheumatology
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2015

Fingerprint

Systemic Lupus Erythematosus
Immune System
Interferon Type I
Systems Biology
Genetic Polymorphisms
Autoantibodies
Genome
Population

Keywords

  • Autoantibodies
  • Genetics
  • Interferon
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Advances in lupus genetics. / Niewold, Timothy B.

In: Current Opinion in Rheumatology, Vol. 27, No. 5, 01.09.2015, p. 440-447.

Research output: Contribution to journalArticle

Niewold, Timothy B. / Advances in lupus genetics. In: Current Opinion in Rheumatology. 2015 ; Vol. 27, No. 5. pp. 440-447.
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