Advances in drug safety

J. Adam Cartwright, Steven Aniskevich, Christopher B. Robards, Harish Ramakrishna, Sorin J. Brull, Steven R. Clendenen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The operating room offers a unique setting where anesthetics, preoperative medications, patient comorbidities, and surgery all merge. Anesthesiologists are responsible for combining these concerns into a dependable and safe approach. From formulation to administration, enhancements in nearly every aspect of a given drug have improved the ability of anesthesiologists to accomplish this. Some of these methodologies, including novel anesthetics and analgesics, drug delivery and administration including infusion pumps, antithrombotics, and a reappraisal of previous medications are highlighted in this review. While these advancements are significant, patients and healthcare systems globally are rightfully demanding safer application of drugs at every level. On May 1, 2012, a report issued by the Institute of Medicine advised the United States Food and Drug Administration to undertake a much more rigorous patient-centered effort to evaluate a drug's safety over its entire life-cycle. This recommendation is in agreement with the objectives of the Anesthesia Patient Safety Foundation. With these mutual goals shared by many stakeholders and their continued efforts, the future of the estimated 200 million global surgeries to be undertaken this year hopefully provides a safer experience while under anesthesia.

Original languageEnglish (US)
Pages (from-to)6266-6283
Number of pages18
JournalCurrent Pharmaceutical Design
Volume18
Issue number38
DOIs
StatePublished - 2012

Fingerprint

Safety
Anesthetics
Anesthesia
Pharmaceutical Preparations
Infusion Pumps
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
United States Food and Drug Administration
Operating Rooms
Patient Safety
Life Cycle Stages
Analgesics
Comorbidity
Delivery of Health Care
Anesthesiologists

Keywords

  • Anesthetic safety
  • Drug delivery
  • Drug errors
  • Drug safety
  • Perioperative analgesia

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Cartwright, J. A., Aniskevich, S., Robards, C. B., Ramakrishna, H., Brull, S. J., & Clendenen, S. R. (2012). Advances in drug safety. Current Pharmaceutical Design, 18(38), 6266-6283. https://doi.org/10.2174/138161212803832416

Advances in drug safety. / Cartwright, J. Adam; Aniskevich, Steven; Robards, Christopher B.; Ramakrishna, Harish; Brull, Sorin J.; Clendenen, Steven R.

In: Current Pharmaceutical Design, Vol. 18, No. 38, 2012, p. 6266-6283.

Research output: Contribution to journalArticle

Cartwright, JA, Aniskevich, S, Robards, CB, Ramakrishna, H, Brull, SJ & Clendenen, SR 2012, 'Advances in drug safety', Current Pharmaceutical Design, vol. 18, no. 38, pp. 6266-6283. https://doi.org/10.2174/138161212803832416
Cartwright JA, Aniskevich S, Robards CB, Ramakrishna H, Brull SJ, Clendenen SR. Advances in drug safety. Current Pharmaceutical Design. 2012;18(38):6266-6283. https://doi.org/10.2174/138161212803832416
Cartwright, J. Adam ; Aniskevich, Steven ; Robards, Christopher B. ; Ramakrishna, Harish ; Brull, Sorin J. ; Clendenen, Steven R. / Advances in drug safety. In: Current Pharmaceutical Design. 2012 ; Vol. 18, No. 38. pp. 6266-6283.
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