Advances in clinical applications of tissue proteomics: Opportunities and challenges

Ahmet Dogan

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Mass spectrometry (MS)-based proteomics assays provide unprecedented opportunities for determination of protein expression in tissues for clinical applications. Within the last few years a number of clinical assays have been established. These include multiplexed selected reaction monitoring based approaches to quantify protein targets of therapeutic agents in cancer tissues and bottom-up shotgun MS-based proteomics approaches to diagnose and classify protein deposition disorders such as amyloidosis. These examples highlight the vast potential of MS-based proteomics as analytical and descriptive tools for clinical diagnosis of human disease. However, a number of major challenges remain for broader application and acceptance of such technologies in routine clinical care.

Original languageEnglish (US)
Pages (from-to)531-533
Number of pages3
JournalExpert Review of Proteomics
Volume11
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • amyloidosis
  • cancer
  • immunoglobulin
  • mass spectrometry
  • proteomics
  • transthyretin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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