Advances and challenges of nanotechnology-based drug delivery systems

Wen Jiang, Y S Betty Kim, James T. Rutka, Warren C W Chan

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

The ability to deliver highly efficient therapeutic compounds specifically to diseased sites is crucial for effectively treating all human illnesses. Unfortunately, conventional therapeutic strategies require unnecessarily high systemic administration due to non-specific biodistribution and rapid metabolism of free drug molecules prior to reaching their targeted sites. Using the tools of nanotechnology, drug delivery systems within the nanometer size regime can be developed to alter both pharmacological and therapeutic effects of drug molecules. Due to their small size, these novel DDS offer superior advantages, such as altered pharmacokinetic behaviour and improved payload, over traditional large-scale systems. In addition, the relative ease in modifying their surface chemistry permits the attachment of targeting and therapeutic molecules for specific therapeutic applications. Finally, complex nanostructures can be assembled using different building blocks with multiple functionalities ranging from targeting, detecting, imaging and therapeutic capabilities.

Original languageEnglish (US)
Pages (from-to)621-633
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume4
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Nanotechnology
Drug Delivery Systems
Therapeutics
Aptitude
Nanostructures
Therapeutic Uses
Pharmaceutical Preparations
Pharmacokinetics
Pharmacology

Keywords

  • Buckyballs
  • Carbon nanotubes
  • Drug delivery system
  • Liposomes
  • Nanostructures
  • Quantum dots

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Advances and challenges of nanotechnology-based drug delivery systems. / Jiang, Wen; Kim, Y S Betty; Rutka, James T.; Chan, Warren C W.

In: Expert Opinion on Drug Delivery, Vol. 4, No. 6, 11.2007, p. 621-633.

Research output: Contribution to journalReview article

Jiang, Wen ; Kim, Y S Betty ; Rutka, James T. ; Chan, Warren C W. / Advances and challenges of nanotechnology-based drug delivery systems. In: Expert Opinion on Drug Delivery. 2007 ; Vol. 4, No. 6. pp. 621-633.
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