Abstract
Background: Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. Objective: To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. Methods: Case report. Results: Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. Conclusion: Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.
Original language | English (US) |
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Journal | Multiple Sclerosis Journal - Experimental, Translational and Clinical |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - 2019 |
Keywords
- MRI
- Progressive solitary sclerosis
- demyelination
- multiple sclerosis
- myelin water imaging
- neuroimaging
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience