Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

Lisa Eunyoung Lee, Jillian K. Chan, Emilie Nevill, Adam Soares, Irene M. Vavasour, Erin L. Macmillan, Hideki Garren, David Clayton, B. Mark Keegan, Roger Tam, Anthony L. Traboulsee, Shannon H. Kolind, Robert L. Carruthers

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. Objective: To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. Methods: Case report. Results: Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. Conclusion: Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal - Experimental, Translational and Clinical
Volume5
Issue number1
DOIs
StatePublished - 2019

Keywords

  • MRI
  • Progressive solitary sclerosis
  • demyelination
  • multiple sclerosis
  • myelin water imaging
  • neuroimaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?'. Together they form a unique fingerprint.

Cite this