@article{41cd85284de44212bf8c025a02886955,
title = "Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?",
abstract = "Background: Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. Objective: To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. Methods: Case report. Results: Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. Conclusion: Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.",
keywords = "MRI, Progressive solitary sclerosis, demyelination, multiple sclerosis, myelin water imaging, neuroimaging",
author = "Lee, {Lisa Eunyoung} and Chan, {Jillian K.} and Emilie Nevill and Adam Soares and Vavasour, {Irene M.} and Macmillan, {Erin L.} and Hideki Garren and David Clayton and Keegan, {B. Mark} and Roger Tam and Traboulsee, {Anthony L.} and Kolind, {Shannon H.} and Carruthers, {Robert L.}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is supported by Milan & Maureen Ilich Foundation, Genentech and F Hoffmann-La Roche. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is supported by Milan & Maureen Ilich Foundation, Genentech and F Hoffmann-La Roche.The authors would like to thank sincerely the participants and MRI technologists at the UBC MRI Research Centre. They also thank the UBC MS/MRI Research Group for help with generating lesion masks and Ms Carina Graf and Dr Brian Weinshenker for helpful discussions. Publisher Copyright: {\textcopyright} 2019, SAGE Publications Inc.. All rights reserved.",
year = "2019",
doi = "10.1177/2055217318824612",
language = "English (US)",
volume = "5",
journal = "Multiple Sclerosis Journal - Experimental, Translational and Clinical",
issn = "2055-2173",
publisher = "SAGE Publications Inc.",
number = "1",
}