Advanced image reconstruction strategies for 4D prostate DCE-MRI: Steps toward clinical practicality

Eric G. Stinson, Eric A. Borisch, Adam T. Froemming, Akira Kawashima, Phillip M. Young, Brent A. Warndahl, Roger C. Grimm, Armando Manduca, Stephen J Riederer, Joshua D Trazasko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic contrast-enhanced (DCE) MRI is an important tool for the detection and characterization of primary and recurring prostate cancer. Advanced reconstruction strategies (e.g., sparse or low-rank regression) provide improved depiction of contrast dynamics and pharmacokinetic parameters; however, the high computation cost of reconstructing 4D (3D+time, 50+ frames) datasets typically inhibits their routine clinical use. Here, a novel alternating direction method-of-multipliers (ADMM) optimization strategy is described that enables these methods to be executed in ∠5 minutes, and thus within the standard clinical workflow. After overviewing the mechanics of this approach, high-performance implementation strategies will be discussed and demonstrated through clinical cases.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSPIE
Volume9597
ISBN (Print)9781628417630, 9781628417630
DOIs
StatePublished - 2015
EventWavelets and Sparsity XVI - San Diego, United States
Duration: Aug 10 2015Aug 12 2015

Other

OtherWavelets and Sparsity XVI
CountryUnited States
CitySan Diego
Period8/10/158/12/15

Keywords

  • ADMM
  • Clinical Practicality
  • DCE-MRI
  • Sparse Reconstruction

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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    Stinson, E. G., Borisch, E. A., Froemming, A. T., Kawashima, A., Young, P. M., Warndahl, B. A., Grimm, R. C., Manduca, A., Riederer, S. J., & Trazasko, J. D. (2015). Advanced image reconstruction strategies for 4D prostate DCE-MRI: Steps toward clinical practicality. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 9597). [959704] SPIE. https://doi.org/10.1117/12.2188527